Cargando…

Knowledge-Guided “Community Network” Analysis Reveals the Functional Modules and Candidate Targets in Non-Small-Cell Lung Cancer

Non-small-cell lung cancer (NSCLC) represents a heterogeneous group of malignancies that are the leading cause of cancer-related death worldwide. Although many NSCLC-related genes and pathways have been identified, there remains an urgent need to mechanistically understand how these genes and pathwa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Fan, Han, Shuqing, Yang, Ji, Yan, Wenying, Hu, Guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919838/ https://www.ncbi.nlm.nih.gov/pubmed/33669233 http://dx.doi.org/10.3390/cells10020402

Ejemplares similares

Biological Networks for Cancer Candidate Biomarkers Discovery
por: Yan, Wenying, et al.
Publicado: (2016)

Identifying Drug Targets in Pancreatic Ductal Adenocarcinoma Through Machine Learning, Analyzing Biomolecular Networks, and Structural Modeling
por: Yan, Wenying, et al.
Publicado: (2020)

Prior knowledge guided eQTL mapping for identifying candidate genes
por: Wang, Yunli, et al.
Publicado: (2016)

Gene co-expression network analysis to identify critical modules and candidate genes of drought-resistance in wheat
por: Lv, Liangjie, et al.
Publicado: (2020)

De Novo Prediction of Drug Targets and Candidates by Chemical Similarity-Guided Network-Based Inference
por: Vigil-Vásquez, Carlos, et al.
Publicado: (2022)

A curated census of autophagy-modulating proteins and small molecules: Candidate targets for cancer therapy
por: Lorenzi, Philip L, et al.
Publicado: (2014)

A Screening of Epigenetic Therapeutic Targets for Non-Small Cell Lung Cancer Reveals PADI4 and KDM6B as Promising Candidates
por: Lesbon, Jéssika Cristina Chagas, et al.
Publicado: (2022)

Targeting STAT3 signaling overcomes gefitinib resistance in non-small cell lung cancer
por: Liu, Zhe, et al.
Publicado: (2021)

Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases
por: Fan, Hueng-Chuen, et al.
Publicado: (2015)

Developing integrated crop knowledge networks to advance candidate gene discovery
por: Hassani-Pak, Keywan, et al.
Publicado: (2016)

Cellular crosstalk of macrophages and therapeutic implications in non-small cell lung cancer revealed by integrative inference of single-cell transcriptomics
por: Wu, Lei, et al.
Publicado: (2023)

Cultivating communities of practice: a guide to managing knowledge
por: Wenger, Etienne, et al.
Publicado: (2002)

Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis
por: Shen, Qi, et al.
Publicado: (2018)

Knowledge Discovery in Biological Databases for Revealing Candidate Genes Linked to Complex Phenotypes
por: Hassani-Pak, Keywan, et al.
Publicado: (2017)

Structure-Guided Strategies of Targeted Therapies for Patients with EGFR-Mutant Non–Small Cell Lung Cancer
por: Du, Zhenfang, et al.
Publicado: (2023)

Associative gene networks reveal novel candidates important for ADHD and dyslexia comorbidity
por: Hongyao, HE, et al.
Publicado: (2023)

Small RNA sequencing provides candidate miRNA-target pairs for revealing the mechanism of apomixis in Zanthoxylum bungeanum
por: Fei, Xitong, et al.
Publicado: (2021)

A rice protein interaction network reveals high centrality nodes and candidate pathogen effector targets
por: Mishra, Bharat, et al.
Publicado: (2022)

Finding gene regulatory network candidates using the gene expression knowledge base
por: Venkatesan, Aravind, et al.
Publicado: (2014)

Genetic and Targeted eQTL Mapping Reveals Strong Candidate Genes Modulating the Stress Response During Chicken Domestication
por: Fallahsharoudi, Amir, et al.
Publicado: (2016)

Transcriptome and Proteome Data Reveal Candidate Genes for Pollinator Attraction in Sexually Deceptive Orchids
por: Sedeek, Khalid E. M., et al.
Publicado: (2013)

Novel small molecule EGFR inhibitors as candidate drugs in non-small cell lung cancer
por: Berardi, Rossana, et al.
Publicado: (2013)

Regulatory Effect of let-7f Transfection in Non-Small Cell Lung Cancer on its Candidate Target Genes
por: Zafari, Venus, et al.
Publicado: (2022)

Simulations reveal challenges to artificial community selection and possible strategies for success
por: Xie, Li, et al.
Publicado: (2019)

Network motifs modulate druggability of cellular targets
por: Wu, Fan, et al.
Publicado: (2016)

Identification of candidate genes associated with the pathogenesis of small cell lung cancer via integrated bioinformatics analysis
por: Liao, Yi, et al.
Publicado: (2019)

Knowledge-guided convolutional networks for chemical-disease relation extraction
por: Zhou, Huiwei, et al.
Publicado: (2019)

Targeted Molecular Treatments in Non-Small Cell Lung Cancer: A Clinical Guide for Oncologists
por: Bui, Kim Tam, et al.
Publicado: (2018)

Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance
por: Emad, Amin, et al.
Publicado: (2017)

Inferring Gene Regulatory Networks Using Conditional Regulation Pattern to Guide Candidate Genes
por: Xiao, Fei, et al.
Publicado: (2016)

Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data
por: Liu, Hui, et al.
Publicado: (2016)

Computed tomography-guided percutaneous cutting needle biopsy for small (≤ 20 mm) lung nodules
por: Li, Guang-Chao, et al.
Publicado: (2017)

Targeted sequencing reveals candidate causal variants for dairy bull subfertility
por: Abdollahi‐Arpanahi, R., et al.
Publicado: (2021)

Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer
por: Zhang, Wenyu, et al.
Publicado: (2014)

TCM Prescription Generation via Knowledge Source Guidance Network Combined with Herbal Candidate Mechanism
por: Hou, Jiaxin, et al.
Publicado: (2023)

Network Analysis Identifies Drug Targets and Small Molecules to Modulate Apoptosis Resistant Cancers
por: Fathima, Samreen, et al.
Publicado: (2021)

Plasma CXCL14 as a Candidate Biomarker for the Diagnosis of Lung Cancer
por: Tian, Peng-Fei, et al.
Publicado: (2022)

Knowledge-based analyses reveal new candidate genes associated with risk of hepatitis B virus related hepatocellular carcinoma
por: Jiang, Deke, et al.
Publicado: (2020)

Community Structure Reveals Biologically Functional Modules in MEF2C Transcriptional Regulatory Network
por: Alcalá-Corona, Sergio A., et al.
Publicado: (2016)

Elucidation of bioinformatic-guided high-prospect drug repositioning candidates for DMD via Swanson linking of target-focused latent knowledge from text-mined categorical metadata
por: Ulm, J. Wes, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_d9j4d0jhkoeb9os530t8oku6bg