Optimized production and immunogenicity of an insect virus-based chikungunya virus candidate vaccine in cell culture and animal models

A chimeric Eilat/ Chikungunya virus (EILV/CHIKV) was previously reported to replicate only in mosquito cells but capable of inducing robust adaptive immunity in animals. Here, we initially selected C7/10 cells to optimize the production of the chimeric virus. A two-step procedure produced highly pur...

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Detalles Bibliográficos
Autores principales: Adam, Awadalkareem, Luo, Huanle, Osman, Samantha R., Wang, Binbin, Roundy, Christopher M., Auguste, Albert J., Plante, Kenneth S., Peng, Bi-Hung, Thangamani, Saravanan, Frolova, Elena I., Frolov, Ilya, Weaver, Scott C., Wang, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919884/
https://www.ncbi.nlm.nih.gov/pubmed/33539255
http://dx.doi.org/10.1080/22221751.2021.1886598

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