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The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor

Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that lacks effective therapeutic interventions. SARS-CoV-2 infects ACE2-expressing cells and gains cell entry through either direct plasma membrane fusion or endocytosis. Recent studies have shown that in addition to ACE2, heparan sulfate pr...

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Detalles Bibliográficos
Autores principales: Hu, Yanmei, Meng, Xiangzhi, Zhang, Fushun, Xiang, Yan, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919907/
https://www.ncbi.nlm.nih.gov/pubmed/33560940
http://dx.doi.org/10.1080/22221751.2021.1888660

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