Cargando…

Overview of the Assays to Probe O-Linked β-N-Acetylglucosamine Transferase Binding and Activity

O-GlcNAcylation is a posttranslational modification that occurs at serine and threonine residues of protein substrates by the addition of O-linked β-d-N-acetylglucosamine (GlcNAc) moiety. Two enzymes are involved in this modification: O-GlcNac transferase (OGT), which attaches the GlcNAc residue to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Balsollier, Cyril, Pieters, Roland J., Anderluh, Marko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920051/ https://www.ncbi.nlm.nih.gov/pubmed/33669256 http://dx.doi.org/10.3390/molecules26041037

Ejemplares similares

Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition
por: Loi, Elena Maria, et al.
Publicado: (2020)

New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth
por: Weiss, Matjaž, et al.
Publicado: (2021)

Polymorphism in the intron 20 of porcine O-linked N-acetylglucosamine transferase
por: Kim, Jong Gug, et al.
Publicado: (2017)

Epigenetic activation of O-linked β-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia
por: Kampa-Schittenhelm, K.M., et al.
Publicado: (2020)

Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT
por: Meek, Richard W., et al.
Publicado: (2021)

Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability
por: Willems, Anke P., et al.
Publicado: (2017)

A study of the structural properties of sites modified by the O-linked 6-N-acetylglucosamine transferase
por: Britto-Borges, Thiago, et al.
Publicado: (2017)

O-linked N-acetylglucosamine transferase is involved in fine regulation of flowering time in winter wheat
por: Fan, Min, et al.
Publicado: (2021)

O-linked N-acetylglucosamine transferase (OGT) regulates pancreatic α-cell function in mice
por: Essawy, Ahmad, et al.
Publicado: (2021)

O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1
por: Mu, Yongxin, et al.
Publicado: (2020)

Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT)
por: Bauer, Christina, et al.
Publicado: (2015)

O-linked N-acetylglucosamine transferase (OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma
por: Qiao, Zhe, et al.
Publicado: (2012)

Correction: A study of the structural properties of sites modified by the O-linked 6-N-acetylglucosamine transferase
por: Britto-Borges, Thiago, et al.
Publicado: (2017)

O-Linked β-N-Acetylglucosamine Modification: Linking Hypertension and the Immune System
por: dos Passos Junior, Rinaldo Rodrigues, et al.
Publicado: (2022)

Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression
por: Saeed, Muhammad Tariq, et al.
Publicado: (2016)

High O-linked N-acetylglucosamine transferase expression predicts poor survival in patients with early stage lung adenocarcinoma
por: Lin, Yi-Cheng, et al.
Publicado: (2018)

An in vitro assay for enzymatic studies on human ALG13/14 heterodimeric UDP-N-acetylglucosamine transferase
por: Wang, Chun-Di, et al.
Publicado: (2022)

Downregulation of O-linked N-acetylglucosamine transferase by RNA interference decreases MMP9 expression in human esophageal cancer cells
por: QIAO, ZHE, et al.
Publicado: (2016)

Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells
por: Pepe, F, et al.
Publicado: (2017)

O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes
por: Kim, Minjun, et al.
Publicado: (2016)

O-linked N-acetylglucosamine transferase enhances secretory clusterin expression via liver X receptors and sterol response element binding protein regulation in cervical cancer
por: Kim, Min Jun, et al.
Publicado: (2017)

Advances in UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) Covalent Inhibition
por: de Oliveira, Maycon Vinicius Damasceno, et al.
Publicado: (2022)

Targeted Inhibition of O-Linked β-N-Acetylglucosamine Transferase as a Promising Therapeutic Strategy to Restore Chemosensitivity and Attenuate Aggressive Tumor Traits in Chemoresistant Urothelial Carcinoma of the Bladder
por: Lee, Hye Won, et al.
Publicado: (2022)

O-Linked N-Acetylglucosamine Cycling Regulates Mitotic Spindle Organization
por: Tan, Ee Phie, et al.
Publicado: (2013)

MicroRNA-200a/200b Modulate High Glucose-Induced Endothelial Inflammation by Targeting O-linked N-Acetylglucosamine Transferase Expression
por: Lo, Wan-Yu, et al.
Publicado: (2018)

In Situ Imaging of O-Linked β-N-Acetylglucosamine Using On-Tissue Hydrolysis and MALDI Mass Spectrometry
por: Escobar, Edwin E., et al.
Publicado: (2023)

Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening
por: Loi, Elena M., et al.
Publicado: (2022)

Corrigendum: MicroRNA-200a/200b Modulate High Glucose-Induced Endothelial Inflammation by Targeting O-linked N-Acetylglucosamine Transferase Expression
por: Lo, Wan-Yu, et al.
Publicado: (2018)

Silencing of O-linked N-acetylglucosamine transferase ameliorates hypercalcemia-induced neurotoxicity in renal failure by regulating EZH2/KLF2/CXCL1 axis
por: Cao, Yaochen, et al.
Publicado: (2021)

Bromo-Cyclobutenaminones as New Covalent UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors
por: Hamilton, David J., et al.
Publicado: (2020)

Inhibition of O-GlcNAc Transferase Alters the Differentiation and Maturation Process of Human Monocyte Derived Dendritic Cells
por: Weiss, Matjaž, et al.
Publicado: (2021)

Non-canonical Interaction Between O-Linked N-Acetylglucosamine Transferase and miR-146a-5p Aggravates High Glucose-Induced Endothelial Inflammation
por: Lo, Wan-Yu, et al.
Publicado: (2020)

Nuclear pore complex glycoproteins contain cytoplasmically disposed O- linked N-acetylglucosamine
Publicado: (1987)

O-Linked N-Acetylglucosamine Transiently Elevates in HeLa Cells during Mitosis
por: Fisi, Viktória, et al.
Publicado: (2018)

The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase
por: Siala, Wafi, et al.
Publicado: (2016)

Role of O‐linked N‐acetylglucosamine in the homeostasis of metabolic organs, and its potential links with diabetes and its complications
por: Morino, Katsutaro, et al.
Publicado: (2020)

O-linked β-N-acetylglucosamine during hyperglycemia exerts both anti-inflammatory and pro-oxidative properties in the endothelial system
por: Rajapakse, Angana Gupta, et al.
Publicado: (2009)

Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring
por: Moore, Mackenzie, et al.
Publicado: (2021)

Detection of O-Linked-N-Acetylglucosamine Modification and Its Associated Enzymes in Human Degenerated Intervertebral Discs
por: Nikolaou, Georgios, et al.
Publicado: (2017)

Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum
por: Ostrowski, Adam, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_acsf8knt4eiv46afhels4rr26n