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Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population

The purpose of this study was to investigate the association between xanthine oxidoreductase (XOR) activity and a high risk of cardiovascular disease (CVD) in a general Japanese population. The Iwate Tohoku Medical Megabank Organization pooled individual participant data from a general population-ba...

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Autores principales: Kotozaki, Yuka, Satoh, Mamoru, Tanno, Kozo, Ohmomo, Hideki, Otomo, Ryo, Tanaka, Fumitaka, Nasu, Takahito, Taguchi, Satoru, Kikuchi, Hiroto, Kobayashi, Takamasa, Shimizu, Atsushi, Sakata, Kiyomi, Hitomi, Jiro, Sobue, Kenji, Sasaki, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920066/
https://www.ncbi.nlm.nih.gov/pubmed/33669298
http://dx.doi.org/10.3390/ijerph18041894
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author Kotozaki, Yuka
Satoh, Mamoru
Tanno, Kozo
Ohmomo, Hideki
Otomo, Ryo
Tanaka, Fumitaka
Nasu, Takahito
Taguchi, Satoru
Kikuchi, Hiroto
Kobayashi, Takamasa
Shimizu, Atsushi
Sakata, Kiyomi
Hitomi, Jiro
Sobue, Kenji
Sasaki, Makoto
author_facet Kotozaki, Yuka
Satoh, Mamoru
Tanno, Kozo
Ohmomo, Hideki
Otomo, Ryo
Tanaka, Fumitaka
Nasu, Takahito
Taguchi, Satoru
Kikuchi, Hiroto
Kobayashi, Takamasa
Shimizu, Atsushi
Sakata, Kiyomi
Hitomi, Jiro
Sobue, Kenji
Sasaki, Makoto
author_sort Kotozaki, Yuka
collection PubMed
description The purpose of this study was to investigate the association between xanthine oxidoreductase (XOR) activity and a high risk of cardiovascular disease (CVD) in a general Japanese population. The Iwate Tohoku Medical Megabank Organization pooled individual participant data from a general population-based cohort study in Iwate prefecture. The cardiovascular risk was calculated using the Framingham Risk Score (FRS). A total of 1605 of the 1631 participants (98.4%) had detectable XOR activity. Multiple regression analysis demonstrated that XOR activity was independently associated with body mass index (β = 0.26, p < 0.001), diabetes (β = 0.09, p < 0.001), dyslipidemia (β = 0.08, p = 0.001), and uric acid (β = 0.13, p < 0.001). Multivariate analysis showed that the highest quartile of XOR activity was associated with a high risk for CVD (FRS ≥ 15) after adjustment for baseline characteristics (OR 2.93, 95% CI 1.16–7.40). The area under the receiver operating characteristic curves of the FRS with XOR activity was 0.81 (p = 0.008). XOR activity is associated with a high risk for CVD, suggesting that high XOR activity may indicate cardiovascular risk in a general Japanese population.
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spelling pubmed-79200662021-03-02 Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population Kotozaki, Yuka Satoh, Mamoru Tanno, Kozo Ohmomo, Hideki Otomo, Ryo Tanaka, Fumitaka Nasu, Takahito Taguchi, Satoru Kikuchi, Hiroto Kobayashi, Takamasa Shimizu, Atsushi Sakata, Kiyomi Hitomi, Jiro Sobue, Kenji Sasaki, Makoto Int J Environ Res Public Health Article The purpose of this study was to investigate the association between xanthine oxidoreductase (XOR) activity and a high risk of cardiovascular disease (CVD) in a general Japanese population. The Iwate Tohoku Medical Megabank Organization pooled individual participant data from a general population-based cohort study in Iwate prefecture. The cardiovascular risk was calculated using the Framingham Risk Score (FRS). A total of 1605 of the 1631 participants (98.4%) had detectable XOR activity. Multiple regression analysis demonstrated that XOR activity was independently associated with body mass index (β = 0.26, p < 0.001), diabetes (β = 0.09, p < 0.001), dyslipidemia (β = 0.08, p = 0.001), and uric acid (β = 0.13, p < 0.001). Multivariate analysis showed that the highest quartile of XOR activity was associated with a high risk for CVD (FRS ≥ 15) after adjustment for baseline characteristics (OR 2.93, 95% CI 1.16–7.40). The area under the receiver operating characteristic curves of the FRS with XOR activity was 0.81 (p = 0.008). XOR activity is associated with a high risk for CVD, suggesting that high XOR activity may indicate cardiovascular risk in a general Japanese population. MDPI 2021-02-16 2021-02 /pmc/articles/PMC7920066/ /pubmed/33669298 http://dx.doi.org/10.3390/ijerph18041894 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kotozaki, Yuka
Satoh, Mamoru
Tanno, Kozo
Ohmomo, Hideki
Otomo, Ryo
Tanaka, Fumitaka
Nasu, Takahito
Taguchi, Satoru
Kikuchi, Hiroto
Kobayashi, Takamasa
Shimizu, Atsushi
Sakata, Kiyomi
Hitomi, Jiro
Sobue, Kenji
Sasaki, Makoto
Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population
title Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population
title_full Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population
title_fullStr Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population
title_full_unstemmed Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population
title_short Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population
title_sort plasma xanthine oxidoreductase activity is associated with a high risk of cardiovascular disease in a general japanese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920066/
https://www.ncbi.nlm.nih.gov/pubmed/33669298
http://dx.doi.org/10.3390/ijerph18041894
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