Atorvastatin-Induced Necrotizing Myopathy and its Response to Combination Therapy

Atorvastatin is the most commonly used statin medication to decrease cholesterol levels and prevent atherosclerosis. Myopathy is a reported side effect of atorvastatin which can happen even after more than six months after starting the medication. The side effect on the muscle tissue can range from...

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Autores principales: Boppana, Sri Harsha, Syed, Hasan A, Antwi-Amoabeng, Daniel, Reddy, Prahlad, Gullapalli, Nageshwara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920241/
https://www.ncbi.nlm.nih.gov/pubmed/33659112
http://dx.doi.org/10.7759/cureus.12957
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author Boppana, Sri Harsha
Syed, Hasan A
Antwi-Amoabeng, Daniel
Reddy, Prahlad
Gullapalli, Nageshwara
author_facet Boppana, Sri Harsha
Syed, Hasan A
Antwi-Amoabeng, Daniel
Reddy, Prahlad
Gullapalli, Nageshwara
author_sort Boppana, Sri Harsha
collection PubMed
description Atorvastatin is the most commonly used statin medication to decrease cholesterol levels and prevent atherosclerosis. Myopathy is a reported side effect of atorvastatin which can happen even after more than six months after starting the medication. The side effect on the muscle tissue can range from simple reversible myalgia to respiratory muscle compromise. Here we present a 46-year-old male who presented with myopathy after taking atorvastatin for two years. Biopsy proved immune-mediated necrotizing myopathy which responded to a combination of Rituximab and intravenous immunoglobulin therapy.
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spelling pubmed-79202412021-03-02 Atorvastatin-Induced Necrotizing Myopathy and its Response to Combination Therapy Boppana, Sri Harsha Syed, Hasan A Antwi-Amoabeng, Daniel Reddy, Prahlad Gullapalli, Nageshwara Cureus Internal Medicine Atorvastatin is the most commonly used statin medication to decrease cholesterol levels and prevent atherosclerosis. Myopathy is a reported side effect of atorvastatin which can happen even after more than six months after starting the medication. The side effect on the muscle tissue can range from simple reversible myalgia to respiratory muscle compromise. Here we present a 46-year-old male who presented with myopathy after taking atorvastatin for two years. Biopsy proved immune-mediated necrotizing myopathy which responded to a combination of Rituximab and intravenous immunoglobulin therapy. Cureus 2021-01-28 /pmc/articles/PMC7920241/ /pubmed/33659112 http://dx.doi.org/10.7759/cureus.12957 Text en Copyright © 2021, Boppana et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Boppana, Sri Harsha
Syed, Hasan A
Antwi-Amoabeng, Daniel
Reddy, Prahlad
Gullapalli, Nageshwara
Atorvastatin-Induced Necrotizing Myopathy and its Response to Combination Therapy
title Atorvastatin-Induced Necrotizing Myopathy and its Response to Combination Therapy
title_full Atorvastatin-Induced Necrotizing Myopathy and its Response to Combination Therapy
title_fullStr Atorvastatin-Induced Necrotizing Myopathy and its Response to Combination Therapy
title_full_unstemmed Atorvastatin-Induced Necrotizing Myopathy and its Response to Combination Therapy
title_short Atorvastatin-Induced Necrotizing Myopathy and its Response to Combination Therapy
title_sort atorvastatin-induced necrotizing myopathy and its response to combination therapy
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920241/
https://www.ncbi.nlm.nih.gov/pubmed/33659112
http://dx.doi.org/10.7759/cureus.12957
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