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Redox Regulation of PTEN by Peroxiredoxins

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known as a tumor suppressor gene that is frequently mutated in numerous human cancers and inherited syndromes. PTEN functions as a negative regulator of PI3K/Akt signaling pathway by dephosphorylating phosphatidylinositol (3, 4, 5)-tr...

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Autores principales: Nguyen Huu, Thang, Park, Jiyoung, Zhang, Ying, Park, Iha, Yoon, Hyun Joong, Woo, Hyun Ae, Lee, Seung-Rock
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920247/
https://www.ncbi.nlm.nih.gov/pubmed/33669370
http://dx.doi.org/10.3390/antiox10020302
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author Nguyen Huu, Thang
Park, Jiyoung
Zhang, Ying
Park, Iha
Yoon, Hyun Joong
Woo, Hyun Ae
Lee, Seung-Rock
author_facet Nguyen Huu, Thang
Park, Jiyoung
Zhang, Ying
Park, Iha
Yoon, Hyun Joong
Woo, Hyun Ae
Lee, Seung-Rock
author_sort Nguyen Huu, Thang
collection PubMed
description Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known as a tumor suppressor gene that is frequently mutated in numerous human cancers and inherited syndromes. PTEN functions as a negative regulator of PI3K/Akt signaling pathway by dephosphorylating phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3) to phosphatidylinositol (4, 5)-bisphosphate (PIP2), which leads to the inhibition of cell growth, proliferation, cell survival, and protein synthesis. PTEN contains a cysteine residue in the active site that can be oxidized by peroxides, forming an intramolecular disulfide bond between Cys(124) and Cys(71). Redox regulation of PTEN by reactive oxygen species (ROS) plays a crucial role in cellular signaling. Peroxiredoxins (Prxs) are a superfamily of peroxidase that catalyzes reduction of peroxides and maintains redox homeostasis. Mammalian Prxs have 6 isoforms (I-VI) and can scavenge cellular peroxides. It has been demonstrated that Prx I can preserve and promote the tumor-suppressive function of PTEN by preventing oxidation of PTEN under benign oxidative stress via direct interaction. Also, Prx II-deficient cells increased PTEN oxidation and insulin sensitivity. Furthermore, Prx III has been shown to protect PTEN from oxidation induced by 15s-HpETE and 12s-HpETE, these are potent inflammatory and pro-oxidant mediators. Understanding the tight connection between PTEN and Prxs is important for providing novel therapies. Herein, we summarized recent studies focusing on the relationship of Prxs and the redox regulation of PTEN.
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spelling pubmed-79202472021-03-02 Redox Regulation of PTEN by Peroxiredoxins Nguyen Huu, Thang Park, Jiyoung Zhang, Ying Park, Iha Yoon, Hyun Joong Woo, Hyun Ae Lee, Seung-Rock Antioxidants (Basel) Review Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known as a tumor suppressor gene that is frequently mutated in numerous human cancers and inherited syndromes. PTEN functions as a negative regulator of PI3K/Akt signaling pathway by dephosphorylating phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3) to phosphatidylinositol (4, 5)-bisphosphate (PIP2), which leads to the inhibition of cell growth, proliferation, cell survival, and protein synthesis. PTEN contains a cysteine residue in the active site that can be oxidized by peroxides, forming an intramolecular disulfide bond between Cys(124) and Cys(71). Redox regulation of PTEN by reactive oxygen species (ROS) plays a crucial role in cellular signaling. Peroxiredoxins (Prxs) are a superfamily of peroxidase that catalyzes reduction of peroxides and maintains redox homeostasis. Mammalian Prxs have 6 isoforms (I-VI) and can scavenge cellular peroxides. It has been demonstrated that Prx I can preserve and promote the tumor-suppressive function of PTEN by preventing oxidation of PTEN under benign oxidative stress via direct interaction. Also, Prx II-deficient cells increased PTEN oxidation and insulin sensitivity. Furthermore, Prx III has been shown to protect PTEN from oxidation induced by 15s-HpETE and 12s-HpETE, these are potent inflammatory and pro-oxidant mediators. Understanding the tight connection between PTEN and Prxs is important for providing novel therapies. Herein, we summarized recent studies focusing on the relationship of Prxs and the redox regulation of PTEN. MDPI 2021-02-16 /pmc/articles/PMC7920247/ /pubmed/33669370 http://dx.doi.org/10.3390/antiox10020302 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nguyen Huu, Thang
Park, Jiyoung
Zhang, Ying
Park, Iha
Yoon, Hyun Joong
Woo, Hyun Ae
Lee, Seung-Rock
Redox Regulation of PTEN by Peroxiredoxins
title Redox Regulation of PTEN by Peroxiredoxins
title_full Redox Regulation of PTEN by Peroxiredoxins
title_fullStr Redox Regulation of PTEN by Peroxiredoxins
title_full_unstemmed Redox Regulation of PTEN by Peroxiredoxins
title_short Redox Regulation of PTEN by Peroxiredoxins
title_sort redox regulation of pten by peroxiredoxins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920247/
https://www.ncbi.nlm.nih.gov/pubmed/33669370
http://dx.doi.org/10.3390/antiox10020302
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