De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

We developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular host proteins to infect the cell. Our pipeline allowed the design, validation, and optimization of de novo human angiotensin-converting enzyme 2 (hACE2) decoys to neutraliz...

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Detalles Bibliográficos
Autores principales: Linsky, Thomas W., Vergara, Renan, Codina, Nuria, Nelson, Jorgen W., Walker, Matthew J., Su, Wen, Barnes, Christopher O., Hsiang, Tien-Ying, Esser-Nobis, Katharina, Yu, Kevin, Reneer, Z. Beau, Hou, Yixuan J., Priya, Tanu, Mitsumoto, Masaya, Pong, Avery, Lau, Uland Y., Mason, Marsha L., Chen, Jerry, Chen, Alex, Berrocal, Tania, Peng, Hong, Clairmont, Nicole S., Castellanos, Javier, Lin, Yu-Ru, Josephson-Day, Anna, Baric, Ralph S., Fuller, Deborah H., Walkey, Carl D., Ross, Ted M., Swanson, Ryan, Bjorkman, Pamela J., Gale, Michael, Blancas-Mejia, Luis M., Yen, Hui-Ling, Silva, Daniel-Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920261/
https://www.ncbi.nlm.nih.gov/pubmed/33154107
http://dx.doi.org/10.1126/science.abe0075

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