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Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases

Increased activity of dipeptidyl peptidase IV (DPP-IV) was reported earlier in patients with different types of mucopolysaccharidoses. DPP-IV (also known as CD26 lymphocyte T surface antigen) is a transmembrane protein showing protease activity. This enzyme displays various functions in the organism...

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Autores principales: Ługowska, Agnieszka, Baydakova, Galina, Ilyushkina, Alex, Zakharova, Ekaterina, Mierzewska, Hanna, Szymańska, Krystyna, Wierzba, Jolanta, Kubalska, Jolanta, Graban, Ałła, Kmieć, Tomasz, Perkowska-Sumiła, Barbara, Tylki-Szymańska, Anna, Bednarska-Makaruk, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920438/
https://www.ncbi.nlm.nih.gov/pubmed/33669444
http://dx.doi.org/10.3390/diagnostics11020320
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author Ługowska, Agnieszka
Baydakova, Galina
Ilyushkina, Alex
Zakharova, Ekaterina
Mierzewska, Hanna
Szymańska, Krystyna
Wierzba, Jolanta
Kubalska, Jolanta
Graban, Ałła
Kmieć, Tomasz
Perkowska-Sumiła, Barbara
Tylki-Szymańska, Anna
Bednarska-Makaruk, Małgorzata
author_facet Ługowska, Agnieszka
Baydakova, Galina
Ilyushkina, Alex
Zakharova, Ekaterina
Mierzewska, Hanna
Szymańska, Krystyna
Wierzba, Jolanta
Kubalska, Jolanta
Graban, Ałła
Kmieć, Tomasz
Perkowska-Sumiła, Barbara
Tylki-Szymańska, Anna
Bednarska-Makaruk, Małgorzata
author_sort Ługowska, Agnieszka
collection PubMed
description Increased activity of dipeptidyl peptidase IV (DPP-IV) was reported earlier in patients with different types of mucopolysaccharidoses. DPP-IV (also known as CD26 lymphocyte T surface antigen) is a transmembrane protein showing protease activity. This enzyme displays various functions in the organism and plays an important role in multiple processes like glucose metabolism, nociception, cell-adhesion, psychoneuroendocrine regulation, immune response and cardiovascular adaptation. In order to evaluate DPP-IV in lysosomal storage diseases (LSD), we examined its activity in plasma samples from 307 patients affected with 24 different LSDs and in 75 control persons. Our results revealed elevated DPP-IV activity especially in individuals affected with mucolipidosis II/III, alpha-mannosidosis, and mucopolysaccharidoses types III, II, and I (p < 0.05). In other LSDs the DPP-IV activity was still significantly increased, but to a lesser extent. In patients with Gaucher disease, ceroid lipofuscinosis type 1 (CLN1), Niemann–Pick disease type C and A, Krabbe and Pompe diseases, gangliosidosis GM2 and metachromatic leukodystrophy discreet or no changes in DPP-IV activity were observed. DPP-IV may serve as a first-tier diagnostic procedure or additional biochemical analysis in recognizing patients with some LSDs. DPP-IV may become an object of basic research for a better understanding of LSDs.
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spelling pubmed-79204382021-03-02 Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases Ługowska, Agnieszka Baydakova, Galina Ilyushkina, Alex Zakharova, Ekaterina Mierzewska, Hanna Szymańska, Krystyna Wierzba, Jolanta Kubalska, Jolanta Graban, Ałła Kmieć, Tomasz Perkowska-Sumiła, Barbara Tylki-Szymańska, Anna Bednarska-Makaruk, Małgorzata Diagnostics (Basel) Article Increased activity of dipeptidyl peptidase IV (DPP-IV) was reported earlier in patients with different types of mucopolysaccharidoses. DPP-IV (also known as CD26 lymphocyte T surface antigen) is a transmembrane protein showing protease activity. This enzyme displays various functions in the organism and plays an important role in multiple processes like glucose metabolism, nociception, cell-adhesion, psychoneuroendocrine regulation, immune response and cardiovascular adaptation. In order to evaluate DPP-IV in lysosomal storage diseases (LSD), we examined its activity in plasma samples from 307 patients affected with 24 different LSDs and in 75 control persons. Our results revealed elevated DPP-IV activity especially in individuals affected with mucolipidosis II/III, alpha-mannosidosis, and mucopolysaccharidoses types III, II, and I (p < 0.05). In other LSDs the DPP-IV activity was still significantly increased, but to a lesser extent. In patients with Gaucher disease, ceroid lipofuscinosis type 1 (CLN1), Niemann–Pick disease type C and A, Krabbe and Pompe diseases, gangliosidosis GM2 and metachromatic leukodystrophy discreet or no changes in DPP-IV activity were observed. DPP-IV may serve as a first-tier diagnostic procedure or additional biochemical analysis in recognizing patients with some LSDs. DPP-IV may become an object of basic research for a better understanding of LSDs. MDPI 2021-02-16 /pmc/articles/PMC7920438/ /pubmed/33669444 http://dx.doi.org/10.3390/diagnostics11020320 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ługowska, Agnieszka
Baydakova, Galina
Ilyushkina, Alex
Zakharova, Ekaterina
Mierzewska, Hanna
Szymańska, Krystyna
Wierzba, Jolanta
Kubalska, Jolanta
Graban, Ałła
Kmieć, Tomasz
Perkowska-Sumiła, Barbara
Tylki-Szymańska, Anna
Bednarska-Makaruk, Małgorzata
Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases
title Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases
title_full Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases
title_fullStr Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases
title_full_unstemmed Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases
title_short Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases
title_sort elevated dipeptidyl peptidase iv (dpp-iv) activity in plasma from patients with various lysosomal diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920438/
https://www.ncbi.nlm.nih.gov/pubmed/33669444
http://dx.doi.org/10.3390/diagnostics11020320
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