Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States

Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHOs) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isola...

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Autores principales: Randad, Pranay R., Larsen, Jesper, Kaya, Hülya, Pisanic, Nora, Ordak, Carly, Price, Lance B., Aziz, Maliha, Nadimpalli, Maya L., Rhodes, Sarah, Stewart, Jill R., Love, Dave C., Mohr, David, Davis, Meghan F., Miller, Lloyd S., Hall, Devon, Carroll, Karen C., Perl, Trish M., Heaney, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920674/
https://www.ncbi.nlm.nih.gov/pubmed/33622471
http://dx.doi.org/10.3201/eid2703.191775
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author Randad, Pranay R.
Larsen, Jesper
Kaya, Hülya
Pisanic, Nora
Ordak, Carly
Price, Lance B.
Aziz, Maliha
Nadimpalli, Maya L.
Rhodes, Sarah
Stewart, Jill R.
Love, Dave C.
Mohr, David
Davis, Meghan F.
Miller, Lloyd S.
Hall, Devon
Carroll, Karen C.
Perl, Trish M.
Heaney, Christopher D.
author_facet Randad, Pranay R.
Larsen, Jesper
Kaya, Hülya
Pisanic, Nora
Ordak, Carly
Price, Lance B.
Aziz, Maliha
Nadimpalli, Maya L.
Rhodes, Sarah
Stewart, Jill R.
Love, Dave C.
Mohr, David
Davis, Meghan F.
Miller, Lloyd S.
Hall, Devon
Carroll, Karen C.
Perl, Trish M.
Heaney, Christopher D.
author_sort Randad, Pranay R.
collection PubMed
description Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHOs) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0–34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina.
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spelling pubmed-79206742021-03-04 Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States Randad, Pranay R. Larsen, Jesper Kaya, Hülya Pisanic, Nora Ordak, Carly Price, Lance B. Aziz, Maliha Nadimpalli, Maya L. Rhodes, Sarah Stewart, Jill R. Love, Dave C. Mohr, David Davis, Meghan F. Miller, Lloyd S. Hall, Devon Carroll, Karen C. Perl, Trish M. Heaney, Christopher D. Emerg Infect Dis Research Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHOs) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0–34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina. Centers for Disease Control and Prevention 2021-03 /pmc/articles/PMC7920674/ /pubmed/33622471 http://dx.doi.org/10.3201/eid2703.191775 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Randad, Pranay R.
Larsen, Jesper
Kaya, Hülya
Pisanic, Nora
Ordak, Carly
Price, Lance B.
Aziz, Maliha
Nadimpalli, Maya L.
Rhodes, Sarah
Stewart, Jill R.
Love, Dave C.
Mohr, David
Davis, Meghan F.
Miller, Lloyd S.
Hall, Devon
Carroll, Karen C.
Perl, Trish M.
Heaney, Christopher D.
Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States
title Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States
title_full Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States
title_fullStr Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States
title_full_unstemmed Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States
title_short Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States
title_sort transmission of antimicrobial-resistant staphylococcus aureus clonal complex 9 between pigs and humans, united states
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920674/
https://www.ncbi.nlm.nih.gov/pubmed/33622471
http://dx.doi.org/10.3201/eid2703.191775
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