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Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012–2016
Tuberculosis (TB) elimination requires interrupting transmission of Mycobacterium tuberculosis. We used a multidisciplinary approach to describe TB transmission in 2 sociodemographically distinct districts in Botswana (Kopanyo Study). During August 2012–March 2016, all patients who had TB were enrol...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920683/ https://www.ncbi.nlm.nih.gov/pubmed/33622470 http://dx.doi.org/10.3201/eid2703.203840 |
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author | Zetola, Nicola M. Moonan, Patrick K. Click, Eleanor Oeltmann, John E. Basotli, Joyce Wen, Xiao-Jun Boyd, Rosanna Tobias, James L. Finlay, Alyssa Modongo, Chawangwa |
author_facet | Zetola, Nicola M. Moonan, Patrick K. Click, Eleanor Oeltmann, John E. Basotli, Joyce Wen, Xiao-Jun Boyd, Rosanna Tobias, James L. Finlay, Alyssa Modongo, Chawangwa |
author_sort | Zetola, Nicola M. |
collection | PubMed |
description | Tuberculosis (TB) elimination requires interrupting transmission of Mycobacterium tuberculosis. We used a multidisciplinary approach to describe TB transmission in 2 sociodemographically distinct districts in Botswana (Kopanyo Study). During August 2012–March 2016, all patients who had TB were enrolled, their sputum samples were cultured, and M. tuberculosis isolates were genotyped by using 24-locus mycobacterial interspersed repetitive units–variable number of tandem repeats. Of 5,515 TB patients, 4,331 (79%) were enrolled. Annualized TB incidence varied by geography (range 66–1,140 TB patients/100,000 persons). A total of 1,796 patient isolates had valid genotyping results and residential geocoordinates; 780 (41%) patients were involved in a localized TB transmission event. Residence in areas with a high burden of TB, age <24 years, being a current smoker, and unemployment were factors associated with localized transmission events. Patients with known HIV-positive status had lower odds of being involved in localized transmission. |
format | Online Article Text |
id | pubmed-7920683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-79206832021-03-04 Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012–2016 Zetola, Nicola M. Moonan, Patrick K. Click, Eleanor Oeltmann, John E. Basotli, Joyce Wen, Xiao-Jun Boyd, Rosanna Tobias, James L. Finlay, Alyssa Modongo, Chawangwa Emerg Infect Dis Research Tuberculosis (TB) elimination requires interrupting transmission of Mycobacterium tuberculosis. We used a multidisciplinary approach to describe TB transmission in 2 sociodemographically distinct districts in Botswana (Kopanyo Study). During August 2012–March 2016, all patients who had TB were enrolled, their sputum samples were cultured, and M. tuberculosis isolates were genotyped by using 24-locus mycobacterial interspersed repetitive units–variable number of tandem repeats. Of 5,515 TB patients, 4,331 (79%) were enrolled. Annualized TB incidence varied by geography (range 66–1,140 TB patients/100,000 persons). A total of 1,796 patient isolates had valid genotyping results and residential geocoordinates; 780 (41%) patients were involved in a localized TB transmission event. Residence in areas with a high burden of TB, age <24 years, being a current smoker, and unemployment were factors associated with localized transmission events. Patients with known HIV-positive status had lower odds of being involved in localized transmission. Centers for Disease Control and Prevention 2021-03 /pmc/articles/PMC7920683/ /pubmed/33622470 http://dx.doi.org/10.3201/eid2703.203840 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Zetola, Nicola M. Moonan, Patrick K. Click, Eleanor Oeltmann, John E. Basotli, Joyce Wen, Xiao-Jun Boyd, Rosanna Tobias, James L. Finlay, Alyssa Modongo, Chawangwa Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012–2016 |
title | Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012–2016 |
title_full | Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012–2016 |
title_fullStr | Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012–2016 |
title_full_unstemmed | Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012–2016 |
title_short | Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012–2016 |
title_sort | population-based geospatial and molecular epidemiologic study of tuberculosis transmission dynamics, botswana, 2012–2016 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920683/ https://www.ncbi.nlm.nih.gov/pubmed/33622470 http://dx.doi.org/10.3201/eid2703.203840 |
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