Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage

Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS) following intracerebral hemorrhage (ICH) and plays an important role in secondary brain injury caused by the inflammatory response, apoptosis, autophagy, and blood-brain barrier (BBB) disruption. This review summar...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Zhenjia, Bai, Qinqin, Wang, Gaiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920740/
https://www.ncbi.nlm.nih.gov/pubmed/33688394
http://dx.doi.org/10.1155/2021/8815441
_version_ 1783658340591599616
author Yao, Zhenjia
Bai, Qinqin
Wang, Gaiqing
author_facet Yao, Zhenjia
Bai, Qinqin
Wang, Gaiqing
author_sort Yao, Zhenjia
collection PubMed
description Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS) following intracerebral hemorrhage (ICH) and plays an important role in secondary brain injury caused by the inflammatory response, apoptosis, autophagy, and blood-brain barrier (BBB) disruption. This review summarizes the current state of knowledge regarding the pathogenic mechanisms of brain injury after ICH, markers for detecting OS, and therapeutic strategies that target OS to mitigate brain injury.
format Online
Article
Text
id pubmed-7920740
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-79207402021-03-08 Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage Yao, Zhenjia Bai, Qinqin Wang, Gaiqing Oxid Med Cell Longev Review Article Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS) following intracerebral hemorrhage (ICH) and plays an important role in secondary brain injury caused by the inflammatory response, apoptosis, autophagy, and blood-brain barrier (BBB) disruption. This review summarizes the current state of knowledge regarding the pathogenic mechanisms of brain injury after ICH, markers for detecting OS, and therapeutic strategies that target OS to mitigate brain injury. Hindawi 2021-02-21 /pmc/articles/PMC7920740/ /pubmed/33688394 http://dx.doi.org/10.1155/2021/8815441 Text en Copyright © 2021 Zhenjia Yao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yao, Zhenjia
Bai, Qinqin
Wang, Gaiqing
Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage
title Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage
title_full Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage
title_fullStr Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage
title_full_unstemmed Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage
title_short Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage
title_sort mechanisms of oxidative stress and therapeutic targets following intracerebral hemorrhage
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920740/
https://www.ncbi.nlm.nih.gov/pubmed/33688394
http://dx.doi.org/10.1155/2021/8815441
work_keys_str_mv AT yaozhenjia mechanismsofoxidativestressandtherapeutictargetsfollowingintracerebralhemorrhage
AT baiqinqin mechanismsofoxidativestressandtherapeutictargetsfollowingintracerebralhemorrhage
AT wanggaiqing mechanismsofoxidativestressandtherapeutictargetsfollowingintracerebralhemorrhage

Ejemplares similares