Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments

Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them. 2-Aminoquinazolin-4(3H)-one derivatives were newly designed, synthesized, and investigated to show the inhibitory effects on SARS-CoV-2 and MERS-CoV. Among the synthesized derivatives, 7...

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Detalles Bibliográficos
Autores principales: Lee, Jun Young, Shin, Young Sup, Jeon, Sangeun, Lee, Se In, Noh, Soojin, Cho, Jung-Eun, Jang, Min Seong, Kim, Seungtaek, Song, Jong Hwan, Kim, Hyoung Rae, Park, Chul Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920804/
https://www.ncbi.nlm.nih.gov/pubmed/33662537
http://dx.doi.org/10.1016/j.bmcl.2021.127885

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