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Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy: a pilot study
PURPOSE: This study aimed to evaluate the clinical and microbiological efficacy of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy (SPT) after initial treatment. METHODS: The participants were 16 men and 8 women (age, 20–65 years) who had...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Academy of Periodontology
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920842/ https://www.ncbi.nlm.nih.gov/pubmed/33634615 http://dx.doi.org/10.5051/jpis.2002720136 |
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author | Choi, EunHa Um, Heung-Sik Chang, Beom-Seok Lee, Si Young Lee, Jae-Kwan |
author_facet | Choi, EunHa Um, Heung-Sik Chang, Beom-Seok Lee, Si Young Lee, Jae-Kwan |
author_sort | Choi, EunHa |
collection | PubMed |
description | PURPOSE: This study aimed to evaluate the clinical and microbiological efficacy of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy (SPT) after initial treatment. METHODS: The participants were 16 men and 8 women (age, 20–65 years) who had at least 15 natural teeth, underwent SPT for more than 1 year due to chronic periodontitis, had 4 or more periodontal pocket sites deeper than 5 mm, and showed >25% gingival bleeding on probing (BoP). They were randomly assigned to the test and control groups. In the test group, mechanical debridement and local antibiotic delivery were performed for all periodontal sulci/pockets; in the control group, mechanical debridement and saline irrigation were performed. In patients who underwent SPT for more than 1 year, clinical and microbiological examinations were performed at baseline and 1 and 3 months after SPT. The clinical examination included an assessment of the periodontal pocket depth, clinical attachment level, plaque index, and BoP. Microbial tests were performed using real-time polymerase chain reaction; the relative ratios of Porphyromonas gingivalis and Fusobacterium nucleatum were determined. RESULTS: Both groups showed significant improvements in clinical parameters at 1 and 3 months from baseline; there were no significant changes between months 1 and 3. Intergroup differences were insignificant. The microbiological analysis revealed no significant differences in P. gingivalis and F. nucleatum ratios across time points. While intergroup differences were insignificant, there was a tendency for the P. gingivalis and F. nucleatum ratios to decrease in the test group. CONCLUSIONS: Mechanical debridement in patients receiving maintenance therapy resulted in clinically significant improvement; the effectiveness of additional local delivery of antibiotics was not significant. The ratios of P. gingivalis and F. nucleatum showed a tendency to decrease in the test group, although it was not significant. |
format | Online Article Text |
id | pubmed-7920842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Academy of Periodontology |
record_format | MEDLINE/PubMed |
spelling | pubmed-79208422021-03-09 Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy: a pilot study Choi, EunHa Um, Heung-Sik Chang, Beom-Seok Lee, Si Young Lee, Jae-Kwan J Periodontal Implant Sci Research Article PURPOSE: This study aimed to evaluate the clinical and microbiological efficacy of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy (SPT) after initial treatment. METHODS: The participants were 16 men and 8 women (age, 20–65 years) who had at least 15 natural teeth, underwent SPT for more than 1 year due to chronic periodontitis, had 4 or more periodontal pocket sites deeper than 5 mm, and showed >25% gingival bleeding on probing (BoP). They were randomly assigned to the test and control groups. In the test group, mechanical debridement and local antibiotic delivery were performed for all periodontal sulci/pockets; in the control group, mechanical debridement and saline irrigation were performed. In patients who underwent SPT for more than 1 year, clinical and microbiological examinations were performed at baseline and 1 and 3 months after SPT. The clinical examination included an assessment of the periodontal pocket depth, clinical attachment level, plaque index, and BoP. Microbial tests were performed using real-time polymerase chain reaction; the relative ratios of Porphyromonas gingivalis and Fusobacterium nucleatum were determined. RESULTS: Both groups showed significant improvements in clinical parameters at 1 and 3 months from baseline; there were no significant changes between months 1 and 3. Intergroup differences were insignificant. The microbiological analysis revealed no significant differences in P. gingivalis and F. nucleatum ratios across time points. While intergroup differences were insignificant, there was a tendency for the P. gingivalis and F. nucleatum ratios to decrease in the test group. CONCLUSIONS: Mechanical debridement in patients receiving maintenance therapy resulted in clinically significant improvement; the effectiveness of additional local delivery of antibiotics was not significant. The ratios of P. gingivalis and F. nucleatum showed a tendency to decrease in the test group, although it was not significant. Korean Academy of Periodontology 2020-12-09 /pmc/articles/PMC7920842/ /pubmed/33634615 http://dx.doi.org/10.5051/jpis.2002720136 Text en Copyright © 2021. Korean Academy of Periodontology https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/). |
spellingShingle | Research Article Choi, EunHa Um, Heung-Sik Chang, Beom-Seok Lee, Si Young Lee, Jae-Kwan Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy: a pilot study |
title | Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy: a pilot study |
title_full | Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy: a pilot study |
title_fullStr | Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy: a pilot study |
title_full_unstemmed | Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy: a pilot study |
title_short | Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline(®)) in patients receiving supportive periodontal therapy: a pilot study |
title_sort | clinical and microbiological effects of adjunctive local delivery of minocycline (periocline(®)) in patients receiving supportive periodontal therapy: a pilot study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920842/ https://www.ncbi.nlm.nih.gov/pubmed/33634615 http://dx.doi.org/10.5051/jpis.2002720136 |
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