Cargando…

Association between Number of Retrieved Sentinel Lymph Nodes and Breast Cancer-related Lymphedema

PURPOSE: Sentinel lymph node biopsy (SLNB) has become a standard axillary staging surgery for early breast cancer, and the proportion of patients requiring axillary lymph node dissection (ALND) is decreasing. We aimed to evaluate the association between the number of sentinel lymph nodes (SLNs) retr...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Hong-Kyu, Ju, Young Wook, Lee, Jun Woo, Kim, Kyoung-Eun, Jung, Jigwang, Kim, Yumi, Lee, Han-Byoel, Moon, Hyeong-Gon, Noh, Dong-Young, Seo, Kwan Sik, Han, Wonshik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Breast Cancer Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920859/
https://www.ncbi.nlm.nih.gov/pubmed/33634621
http://dx.doi.org/10.4048/jbc.2021.24.e9
_version_ 1783658366091919360
author Kim, Hong-Kyu
Ju, Young Wook
Lee, Jun Woo
Kim, Kyoung-Eun
Jung, Jigwang
Kim, Yumi
Lee, Han-Byoel
Moon, Hyeong-Gon
Noh, Dong-Young
Seo, Kwan Sik
Han, Wonshik
author_facet Kim, Hong-Kyu
Ju, Young Wook
Lee, Jun Woo
Kim, Kyoung-Eun
Jung, Jigwang
Kim, Yumi
Lee, Han-Byoel
Moon, Hyeong-Gon
Noh, Dong-Young
Seo, Kwan Sik
Han, Wonshik
author_sort Kim, Hong-Kyu
collection PubMed
description PURPOSE: Sentinel lymph node biopsy (SLNB) has become a standard axillary staging surgery for early breast cancer, and the proportion of patients requiring axillary lymph node dissection (ALND) is decreasing. We aimed to evaluate the association between the number of sentinel lymph nodes (SLNs) retrieved and the risk of lymphedema of the ipsilateral arm. METHODS: Prospectively collected medical records of 910 patients were reviewed. Lymphedema was defined as a difference in circumference > 2 cm compared to the contralateral arm and/or having clinical records of lymphedema treatment in the rehabilitation clinic. RESULTS: Together with an objective and subjective assessment of lymphedema, 36 patients (6.1%) had lymphedema in the SLNB group and 85 patients (27.0%) had lymphedema in the ALND group (p < 0.001). In a multivariate analysis of the whole cohort, risk factors significantly associated risk with the development of lymphedema were body mass index, mastectomy (vs. breast-conserving surgery), ALND, and radiation therapy. In logistic regression models in the SLNB group only, there was no correlation between the number of retrieved SLNs and the incidence of lymphedema. In addition, in the Pearson correlation analysis, no correlation was observed between the number of retrieved SLNs and the difference in circumference between the ipsilateral and contralateral upper extremities (correlation coefficients = 0.067, p = 0.111). CONCLUSION: The risk of lymphedema in breast cancer surgery and adjuvant treatments is multifactorial. The number of retrieved lymph nodes during sentinel biopsy was not associated with the incidence of lymphedema.
format Online
Article
Text
id pubmed-7920859
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Korean Breast Cancer Society
record_format MEDLINE/PubMed
spelling pubmed-79208592021-03-04 Association between Number of Retrieved Sentinel Lymph Nodes and Breast Cancer-related Lymphedema Kim, Hong-Kyu Ju, Young Wook Lee, Jun Woo Kim, Kyoung-Eun Jung, Jigwang Kim, Yumi Lee, Han-Byoel Moon, Hyeong-Gon Noh, Dong-Young Seo, Kwan Sik Han, Wonshik J Breast Cancer Original Article PURPOSE: Sentinel lymph node biopsy (SLNB) has become a standard axillary staging surgery for early breast cancer, and the proportion of patients requiring axillary lymph node dissection (ALND) is decreasing. We aimed to evaluate the association between the number of sentinel lymph nodes (SLNs) retrieved and the risk of lymphedema of the ipsilateral arm. METHODS: Prospectively collected medical records of 910 patients were reviewed. Lymphedema was defined as a difference in circumference > 2 cm compared to the contralateral arm and/or having clinical records of lymphedema treatment in the rehabilitation clinic. RESULTS: Together with an objective and subjective assessment of lymphedema, 36 patients (6.1%) had lymphedema in the SLNB group and 85 patients (27.0%) had lymphedema in the ALND group (p < 0.001). In a multivariate analysis of the whole cohort, risk factors significantly associated risk with the development of lymphedema were body mass index, mastectomy (vs. breast-conserving surgery), ALND, and radiation therapy. In logistic regression models in the SLNB group only, there was no correlation between the number of retrieved SLNs and the incidence of lymphedema. In addition, in the Pearson correlation analysis, no correlation was observed between the number of retrieved SLNs and the difference in circumference between the ipsilateral and contralateral upper extremities (correlation coefficients = 0.067, p = 0.111). CONCLUSION: The risk of lymphedema in breast cancer surgery and adjuvant treatments is multifactorial. The number of retrieved lymph nodes during sentinel biopsy was not associated with the incidence of lymphedema. Korean Breast Cancer Society 2021-02-15 /pmc/articles/PMC7920859/ /pubmed/33634621 http://dx.doi.org/10.4048/jbc.2021.24.e9 Text en © 2021 Korean Breast Cancer Society https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Hong-Kyu
Ju, Young Wook
Lee, Jun Woo
Kim, Kyoung-Eun
Jung, Jigwang
Kim, Yumi
Lee, Han-Byoel
Moon, Hyeong-Gon
Noh, Dong-Young
Seo, Kwan Sik
Han, Wonshik
Association between Number of Retrieved Sentinel Lymph Nodes and Breast Cancer-related Lymphedema
title Association between Number of Retrieved Sentinel Lymph Nodes and Breast Cancer-related Lymphedema
title_full Association between Number of Retrieved Sentinel Lymph Nodes and Breast Cancer-related Lymphedema
title_fullStr Association between Number of Retrieved Sentinel Lymph Nodes and Breast Cancer-related Lymphedema
title_full_unstemmed Association between Number of Retrieved Sentinel Lymph Nodes and Breast Cancer-related Lymphedema
title_short Association between Number of Retrieved Sentinel Lymph Nodes and Breast Cancer-related Lymphedema
title_sort association between number of retrieved sentinel lymph nodes and breast cancer-related lymphedema
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920859/
https://www.ncbi.nlm.nih.gov/pubmed/33634621
http://dx.doi.org/10.4048/jbc.2021.24.e9
work_keys_str_mv AT kimhongkyu associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema
AT juyoungwook associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema
AT leejunwoo associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema
AT kimkyoungeun associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema
AT jungjigwang associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema
AT kimyumi associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema
AT leehanbyoel associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema
AT moonhyeonggon associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema
AT nohdongyoung associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema
AT seokwansik associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema
AT hanwonshik associationbetweennumberofretrievedsentinellymphnodesandbreastcancerrelatedlymphedema