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Impact of Time-Restricted Feeding to Late Night on Adaptation to a 6 h Phase Advance of the Light-Dark Cycle in Mice

In modern society, more and more people suffer from circadian disruption, which in turn affects health. But until now, there are no widely accepted therapies for circadian disorders. Rhythmic feeding behavior is one of the most potent non-photic zeitgebers, thus it has been suggested that it was imp...

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Autores principales: Ren, Baoyin, Ma, Changxiao, Chen, Lihong, FitzGerald, Garret A., Yang, Guangrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920952/
https://www.ncbi.nlm.nih.gov/pubmed/33664675
http://dx.doi.org/10.3389/fphys.2021.634187
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author Ren, Baoyin
Ma, Changxiao
Chen, Lihong
FitzGerald, Garret A.
Yang, Guangrui
author_facet Ren, Baoyin
Ma, Changxiao
Chen, Lihong
FitzGerald, Garret A.
Yang, Guangrui
author_sort Ren, Baoyin
collection PubMed
description In modern society, more and more people suffer from circadian disruption, which in turn affects health. But until now, there are no widely accepted therapies for circadian disorders. Rhythmic feeding behavior is one of the most potent non-photic zeitgebers, thus it has been suggested that it was important to eat during specific periods of time (time-restricted feeding, TRF) so that feeding is aligned with environmental cues under normal light/dark conditions. Here, we challenged mice with a 6 h advanced shift, combined with various approaches to TRF, and found that food restricted to the second half of the nights after the shift facilitated adaptation. This coincided with improved resilience to sepsis. These results raise the possibility of reducing the adverse responses to jet lag by subsequent timing of food intake.
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spelling pubmed-79209522021-03-03 Impact of Time-Restricted Feeding to Late Night on Adaptation to a 6 h Phase Advance of the Light-Dark Cycle in Mice Ren, Baoyin Ma, Changxiao Chen, Lihong FitzGerald, Garret A. Yang, Guangrui Front Physiol Physiology In modern society, more and more people suffer from circadian disruption, which in turn affects health. But until now, there are no widely accepted therapies for circadian disorders. Rhythmic feeding behavior is one of the most potent non-photic zeitgebers, thus it has been suggested that it was important to eat during specific periods of time (time-restricted feeding, TRF) so that feeding is aligned with environmental cues under normal light/dark conditions. Here, we challenged mice with a 6 h advanced shift, combined with various approaches to TRF, and found that food restricted to the second half of the nights after the shift facilitated adaptation. This coincided with improved resilience to sepsis. These results raise the possibility of reducing the adverse responses to jet lag by subsequent timing of food intake. Frontiers Media S.A. 2021-02-16 /pmc/articles/PMC7920952/ /pubmed/33664675 http://dx.doi.org/10.3389/fphys.2021.634187 Text en Copyright © 2021 Ren, Ma, Chen, FitzGerald and Yang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Ren, Baoyin
Ma, Changxiao
Chen, Lihong
FitzGerald, Garret A.
Yang, Guangrui
Impact of Time-Restricted Feeding to Late Night on Adaptation to a 6 h Phase Advance of the Light-Dark Cycle in Mice
title Impact of Time-Restricted Feeding to Late Night on Adaptation to a 6 h Phase Advance of the Light-Dark Cycle in Mice
title_full Impact of Time-Restricted Feeding to Late Night on Adaptation to a 6 h Phase Advance of the Light-Dark Cycle in Mice
title_fullStr Impact of Time-Restricted Feeding to Late Night on Adaptation to a 6 h Phase Advance of the Light-Dark Cycle in Mice
title_full_unstemmed Impact of Time-Restricted Feeding to Late Night on Adaptation to a 6 h Phase Advance of the Light-Dark Cycle in Mice
title_short Impact of Time-Restricted Feeding to Late Night on Adaptation to a 6 h Phase Advance of the Light-Dark Cycle in Mice
title_sort impact of time-restricted feeding to late night on adaptation to a 6 h phase advance of the light-dark cycle in mice
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920952/
https://www.ncbi.nlm.nih.gov/pubmed/33664675
http://dx.doi.org/10.3389/fphys.2021.634187
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