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Locus coeruleus MRI contrast is associated with cortical thickness in older adults
There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC) is important for later-life cognition. Less understood is how LC integrity relates to brain correlates of cognition, such as brain structure. Here, we examined the relationship between cortical thickness and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920995/ https://www.ncbi.nlm.nih.gov/pubmed/33508564 http://dx.doi.org/10.1016/j.neurobiolaging.2020.12.019 |
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author | Bachman, Shelby L. Dahl, Martin J. Werkle-Bergner, Markus Düzel, Sandra Forlim, Caroline Garcia Lindenberger, Ulman Kühn, Simone Mather, Mara |
author_facet | Bachman, Shelby L. Dahl, Martin J. Werkle-Bergner, Markus Düzel, Sandra Forlim, Caroline Garcia Lindenberger, Ulman Kühn, Simone Mather, Mara |
author_sort | Bachman, Shelby L. |
collection | PubMed |
description | There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC) is important for later-life cognition. Less understood is how LC integrity relates to brain correlates of cognition, such as brain structure. Here, we examined the relationship between cortical thickness and a measure reflecting LC integrity in older (n = 229) and younger adults (n = 67). Using a magnetic resonance imaging sequence which yields high signal intensity in the LC, we assessed the contrast between signal intensity of the LC and that of neighboring pontine reference tissue. The Freesurfer software suite was used to quantify cortical thickness. LC contrast was positively related to cortical thickness in older adults, and this association was prominent in parietal, frontal, and occipital regions. Brain regions where LC contrast was related to cortical thickness include portions of the frontoparietal network which have been implicated in noradrenergically modulated cognitive functions. These findings provide novel evidence for a link between LC structure and cortical brain structure in later adulthood. |
format | Online Article Text |
id | pubmed-7920995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-79209952022-04-01 Locus coeruleus MRI contrast is associated with cortical thickness in older adults Bachman, Shelby L. Dahl, Martin J. Werkle-Bergner, Markus Düzel, Sandra Forlim, Caroline Garcia Lindenberger, Ulman Kühn, Simone Mather, Mara Neurobiol Aging Article There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC) is important for later-life cognition. Less understood is how LC integrity relates to brain correlates of cognition, such as brain structure. Here, we examined the relationship between cortical thickness and a measure reflecting LC integrity in older (n = 229) and younger adults (n = 67). Using a magnetic resonance imaging sequence which yields high signal intensity in the LC, we assessed the contrast between signal intensity of the LC and that of neighboring pontine reference tissue. The Freesurfer software suite was used to quantify cortical thickness. LC contrast was positively related to cortical thickness in older adults, and this association was prominent in parietal, frontal, and occipital regions. Brain regions where LC contrast was related to cortical thickness include portions of the frontoparietal network which have been implicated in noradrenergically modulated cognitive functions. These findings provide novel evidence for a link between LC structure and cortical brain structure in later adulthood. 2020-12-29 2021-04 /pmc/articles/PMC7920995/ /pubmed/33508564 http://dx.doi.org/10.1016/j.neurobiolaging.2020.12.019 Text en This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Article Bachman, Shelby L. Dahl, Martin J. Werkle-Bergner, Markus Düzel, Sandra Forlim, Caroline Garcia Lindenberger, Ulman Kühn, Simone Mather, Mara Locus coeruleus MRI contrast is associated with cortical thickness in older adults |
title | Locus coeruleus MRI contrast is associated with cortical thickness in older adults |
title_full | Locus coeruleus MRI contrast is associated with cortical thickness in older adults |
title_fullStr | Locus coeruleus MRI contrast is associated with cortical thickness in older adults |
title_full_unstemmed | Locus coeruleus MRI contrast is associated with cortical thickness in older adults |
title_short | Locus coeruleus MRI contrast is associated with cortical thickness in older adults |
title_sort | locus coeruleus mri contrast is associated with cortical thickness in older adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920995/ https://www.ncbi.nlm.nih.gov/pubmed/33508564 http://dx.doi.org/10.1016/j.neurobiolaging.2020.12.019 |
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