Cargando…
Effect of Intraoperative Goal-Directed Fluid Management on Tissue Oxygen Tension in Obese Patients: a Randomized Controlled Trial
BACKGROUND: Perioperative subcutaneous tissue oxygen tension (PsqO(2)) is substantially reduced in obese surgical patients. Goal-directed fluid therapy optimizes cardiac performance and thus tissue perfusion and oxygen delivery. We therefore tested the hypothesis that intra- and postoperative PsqO(2...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921017/ https://www.ncbi.nlm.nih.gov/pubmed/33244655 http://dx.doi.org/10.1007/s11695-020-05106-x |
_version_ | 1783658388395130880 |
---|---|
author | Mühlbacher, Jakob Luf, Florian Zotti, Oliver Herkner, Harald Fleischmann, Edith Kabon, Barbara |
author_facet | Mühlbacher, Jakob Luf, Florian Zotti, Oliver Herkner, Harald Fleischmann, Edith Kabon, Barbara |
author_sort | Mühlbacher, Jakob |
collection | PubMed |
description | BACKGROUND: Perioperative subcutaneous tissue oxygen tension (PsqO(2)) is substantially reduced in obese surgical patients. Goal-directed fluid therapy optimizes cardiac performance and thus tissue perfusion and oxygen delivery. We therefore tested the hypothesis that intra- and postoperative PsqO(2) is significantly reduced in obese patients undergoing standard fluid management compared to goal-directed fluid administration. METHODS: We randomly assigned 60 obese patients (BMI ≥ 30 kg/m(2)) undergoing laparoscopic bariatric surgery to receive either esophageal Doppler-guided goal-directed fluid management or conventional fluid treatment. Our primary outcome parameter was intra- and postoperative PsqO(2) measured with a polarographic electrode in the subcutaneous tissue of the upper arm. A random effects linear regression model was used to analyze the effect of intervention. RESULTS: Overall, mean (± SD) PsqO(2) was significantly higher in obese patients receiving goal-directed therapy compared to conventional fluid therapy (65.8 ± 28.0 mmHg vs. 53.7 ± 21.7, respectively; repeated measures design adjusted difference: 13.0 mmHg [95% CI 2.3 to 23.7; p = 0.017]). No effect was seen intraoperatively (69.6 ± 27.9 mmHg vs. 61.4 ± 28.8, difference: 9.7 mmHg [95% CI -3.8 to 23.2; p = 0.160]); however, goal-directed fluid management improved PsqO(2) in the early postoperative phase (63.1 ± 27.9 mmHg vs. 48.4 ± 12.5, difference: 14.5 mmHg [95% CI 4.1 to 24.9; p = 0.006]). Intraoperative fluid requirements did not differ between the two groups. CONCLUSIONS: Goal-directed fluid therapy improved subcutaneous tissue oxygenation in obese patients. This effect was more pronounced in the early postoperative period. CLINICAL TRIAL NUMBER AND REGISTRY: The study was registered at ClinicalTrials.gov (NCT 01052519). |
format | Online Article Text |
id | pubmed-7921017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-79210172021-03-19 Effect of Intraoperative Goal-Directed Fluid Management on Tissue Oxygen Tension in Obese Patients: a Randomized Controlled Trial Mühlbacher, Jakob Luf, Florian Zotti, Oliver Herkner, Harald Fleischmann, Edith Kabon, Barbara Obes Surg Original Contributions BACKGROUND: Perioperative subcutaneous tissue oxygen tension (PsqO(2)) is substantially reduced in obese surgical patients. Goal-directed fluid therapy optimizes cardiac performance and thus tissue perfusion and oxygen delivery. We therefore tested the hypothesis that intra- and postoperative PsqO(2) is significantly reduced in obese patients undergoing standard fluid management compared to goal-directed fluid administration. METHODS: We randomly assigned 60 obese patients (BMI ≥ 30 kg/m(2)) undergoing laparoscopic bariatric surgery to receive either esophageal Doppler-guided goal-directed fluid management or conventional fluid treatment. Our primary outcome parameter was intra- and postoperative PsqO(2) measured with a polarographic electrode in the subcutaneous tissue of the upper arm. A random effects linear regression model was used to analyze the effect of intervention. RESULTS: Overall, mean (± SD) PsqO(2) was significantly higher in obese patients receiving goal-directed therapy compared to conventional fluid therapy (65.8 ± 28.0 mmHg vs. 53.7 ± 21.7, respectively; repeated measures design adjusted difference: 13.0 mmHg [95% CI 2.3 to 23.7; p = 0.017]). No effect was seen intraoperatively (69.6 ± 27.9 mmHg vs. 61.4 ± 28.8, difference: 9.7 mmHg [95% CI -3.8 to 23.2; p = 0.160]); however, goal-directed fluid management improved PsqO(2) in the early postoperative phase (63.1 ± 27.9 mmHg vs. 48.4 ± 12.5, difference: 14.5 mmHg [95% CI 4.1 to 24.9; p = 0.006]). Intraoperative fluid requirements did not differ between the two groups. CONCLUSIONS: Goal-directed fluid therapy improved subcutaneous tissue oxygenation in obese patients. This effect was more pronounced in the early postoperative period. CLINICAL TRIAL NUMBER AND REGISTRY: The study was registered at ClinicalTrials.gov (NCT 01052519). Springer US 2020-11-27 2021 /pmc/articles/PMC7921017/ /pubmed/33244655 http://dx.doi.org/10.1007/s11695-020-05106-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Contributions Mühlbacher, Jakob Luf, Florian Zotti, Oliver Herkner, Harald Fleischmann, Edith Kabon, Barbara Effect of Intraoperative Goal-Directed Fluid Management on Tissue Oxygen Tension in Obese Patients: a Randomized Controlled Trial |
title | Effect of Intraoperative Goal-Directed Fluid Management on Tissue Oxygen Tension in Obese Patients: a Randomized Controlled Trial |
title_full | Effect of Intraoperative Goal-Directed Fluid Management on Tissue Oxygen Tension in Obese Patients: a Randomized Controlled Trial |
title_fullStr | Effect of Intraoperative Goal-Directed Fluid Management on Tissue Oxygen Tension in Obese Patients: a Randomized Controlled Trial |
title_full_unstemmed | Effect of Intraoperative Goal-Directed Fluid Management on Tissue Oxygen Tension in Obese Patients: a Randomized Controlled Trial |
title_short | Effect of Intraoperative Goal-Directed Fluid Management on Tissue Oxygen Tension in Obese Patients: a Randomized Controlled Trial |
title_sort | effect of intraoperative goal-directed fluid management on tissue oxygen tension in obese patients: a randomized controlled trial |
topic | Original Contributions |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921017/ https://www.ncbi.nlm.nih.gov/pubmed/33244655 http://dx.doi.org/10.1007/s11695-020-05106-x |
work_keys_str_mv | AT muhlbacherjakob effectofintraoperativegoaldirectedfluidmanagementontissueoxygentensioninobesepatientsarandomizedcontrolledtrial AT lufflorian effectofintraoperativegoaldirectedfluidmanagementontissueoxygentensioninobesepatientsarandomizedcontrolledtrial AT zottioliver effectofintraoperativegoaldirectedfluidmanagementontissueoxygentensioninobesepatientsarandomizedcontrolledtrial AT herknerharald effectofintraoperativegoaldirectedfluidmanagementontissueoxygentensioninobesepatientsarandomizedcontrolledtrial AT fleischmannedith effectofintraoperativegoaldirectedfluidmanagementontissueoxygentensioninobesepatientsarandomizedcontrolledtrial AT kabonbarbara effectofintraoperativegoaldirectedfluidmanagementontissueoxygentensioninobesepatientsarandomizedcontrolledtrial |