Cargando…
The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1
Breast cancer is the leading cause of cancer-related death in women around the world. It is urgently needed to identify genes associated with tumorigenesis and prognosis, as well as to elucidate the molecular mechanisms underlying the oncogenic process. Long noncoding RNAs (lncRNAs) are widely invol...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921111/ https://www.ncbi.nlm.nih.gov/pubmed/33649294 http://dx.doi.org/10.1038/s41420-021-00419-x |
_version_ | 1783658410247454720 |
---|---|
author | Lu, Die Di, Shihao Zhuo, Shuaishuai Zhou, Linyan Bai, Rumeng Ma, Tianshi Zou, Zigui Chen, Chunni Sun, Miaomiao Tang, Jinhai Zhang, Zhihong |
author_facet | Lu, Die Di, Shihao Zhuo, Shuaishuai Zhou, Linyan Bai, Rumeng Ma, Tianshi Zou, Zigui Chen, Chunni Sun, Miaomiao Tang, Jinhai Zhang, Zhihong |
author_sort | Lu, Die |
collection | PubMed |
description | Breast cancer is the leading cause of cancer-related death in women around the world. It is urgently needed to identify genes associated with tumorigenesis and prognosis, as well as to elucidate the molecular mechanisms underlying the oncogenic process. Long noncoding RNAs (lncRNAs) are widely involved in the pathological and physiological processes of organisms and play an important role as oncogenes or tumor suppressor genes, affecting the development and progression of tumors. In this study, we focused on terminal differentiation-induced non-coding RNA (TINCR) (GeneID:257000) and explore its role in the pathogenesis of breast cancer. The results showed that TINCR was increased in breast cancer tissue, and high expression level of TINCR was associated with older age, larger tumor size, and advanced TNM stage. High level of TINCR can promote proliferation and metastasis of breast cancer cells, while downregulation of TINCR induces G1-G0 arrest and apoptosis. Mechanismly, TINCR can bind to staufen1 (STAU1) and then guide STAU1 (GeneID:6780) to bind to OAS1 mRNA (NM_016816.4) to mediate its stability. Thus low level of OAS1(GeneID:4938) can lead to cell proliferation and migration. This result elucidates a new mechanism for TINCR in breast cancer development and provides a survival indicator and potential therapeutic target for breast cancer patients. |
format | Online Article Text |
id | pubmed-7921111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79211112021-03-12 The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1 Lu, Die Di, Shihao Zhuo, Shuaishuai Zhou, Linyan Bai, Rumeng Ma, Tianshi Zou, Zigui Chen, Chunni Sun, Miaomiao Tang, Jinhai Zhang, Zhihong Cell Death Discov Article Breast cancer is the leading cause of cancer-related death in women around the world. It is urgently needed to identify genes associated with tumorigenesis and prognosis, as well as to elucidate the molecular mechanisms underlying the oncogenic process. Long noncoding RNAs (lncRNAs) are widely involved in the pathological and physiological processes of organisms and play an important role as oncogenes or tumor suppressor genes, affecting the development and progression of tumors. In this study, we focused on terminal differentiation-induced non-coding RNA (TINCR) (GeneID:257000) and explore its role in the pathogenesis of breast cancer. The results showed that TINCR was increased in breast cancer tissue, and high expression level of TINCR was associated with older age, larger tumor size, and advanced TNM stage. High level of TINCR can promote proliferation and metastasis of breast cancer cells, while downregulation of TINCR induces G1-G0 arrest and apoptosis. Mechanismly, TINCR can bind to staufen1 (STAU1) and then guide STAU1 (GeneID:6780) to bind to OAS1 mRNA (NM_016816.4) to mediate its stability. Thus low level of OAS1(GeneID:4938) can lead to cell proliferation and migration. This result elucidates a new mechanism for TINCR in breast cancer development and provides a survival indicator and potential therapeutic target for breast cancer patients. Nature Publishing Group UK 2021-03-01 /pmc/articles/PMC7921111/ /pubmed/33649294 http://dx.doi.org/10.1038/s41420-021-00419-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lu, Die Di, Shihao Zhuo, Shuaishuai Zhou, Linyan Bai, Rumeng Ma, Tianshi Zou, Zigui Chen, Chunni Sun, Miaomiao Tang, Jinhai Zhang, Zhihong The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1 |
title | The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1 |
title_full | The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1 |
title_fullStr | The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1 |
title_full_unstemmed | The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1 |
title_short | The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1 |
title_sort | long noncoding rna tincr promotes breast cancer cell proliferation and migration by regulating oas1 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921111/ https://www.ncbi.nlm.nih.gov/pubmed/33649294 http://dx.doi.org/10.1038/s41420-021-00419-x |
work_keys_str_mv | AT ludie thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT dishihao thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT zhuoshuaishuai thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT zhoulinyan thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT bairumeng thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT matianshi thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT zouzigui thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT chenchunni thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT sunmiaomiao thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT tangjinhai thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT zhangzhihong thelongnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT ludie longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT dishihao longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT zhuoshuaishuai longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT zhoulinyan longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT bairumeng longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT matianshi longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT zouzigui longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT chenchunni longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT sunmiaomiao longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT tangjinhai longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 AT zhangzhihong longnoncodingrnatincrpromotesbreastcancercellproliferationandmigrationbyregulatingoas1 |