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Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models
Significant sex differences in terms of prevalence, symptomatic profiles, severity, and comorbidities of psychiatric disorders are quite common. Women have been shown to be more vulnerable to stress and are nearly twice as likely as men to develop stress-related disorders such as depression and anxi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921148/ https://www.ncbi.nlm.nih.gov/pubmed/33664686 http://dx.doi.org/10.3389/fpsyt.2021.644161 |
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author | Takahashi, Aki |
author_facet | Takahashi, Aki |
author_sort | Takahashi, Aki |
collection | PubMed |
description | Significant sex differences in terms of prevalence, symptomatic profiles, severity, and comorbidities of psychiatric disorders are quite common. Women have been shown to be more vulnerable to stress and are nearly twice as likely as men to develop stress-related disorders such as depression and anxiety. Therefore, understanding sex differences with respect to the neurobiological mechanisms underlying stress-related disorders is important for developing more efficient pharmacological interventions for women. However, most preclinical studies on stress-related disorders have focused heavily on male rodents. Here, recent developments in the study of repeated social defeat stress models in female mice are summarized. Our findings suggest that a variety of factors need to be considered when employing this model. |
format | Online Article Text |
id | pubmed-7921148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79211482021-03-03 Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models Takahashi, Aki Front Psychiatry Psychiatry Significant sex differences in terms of prevalence, symptomatic profiles, severity, and comorbidities of psychiatric disorders are quite common. Women have been shown to be more vulnerable to stress and are nearly twice as likely as men to develop stress-related disorders such as depression and anxiety. Therefore, understanding sex differences with respect to the neurobiological mechanisms underlying stress-related disorders is important for developing more efficient pharmacological interventions for women. However, most preclinical studies on stress-related disorders have focused heavily on male rodents. Here, recent developments in the study of repeated social defeat stress models in female mice are summarized. Our findings suggest that a variety of factors need to be considered when employing this model. Frontiers Media S.A. 2021-02-16 /pmc/articles/PMC7921148/ /pubmed/33664686 http://dx.doi.org/10.3389/fpsyt.2021.644161 Text en Copyright © 2021 Takahashi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Takahashi, Aki Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models |
title | Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models |
title_full | Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models |
title_fullStr | Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models |
title_full_unstemmed | Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models |
title_short | Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models |
title_sort | toward understanding the sex differences in the biological mechanism of social stress in mouse models |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921148/ https://www.ncbi.nlm.nih.gov/pubmed/33664686 http://dx.doi.org/10.3389/fpsyt.2021.644161 |
work_keys_str_mv | AT takahashiaki towardunderstandingthesexdifferencesinthebiologicalmechanismofsocialstressinmousemodels |