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Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models

Significant sex differences in terms of prevalence, symptomatic profiles, severity, and comorbidities of psychiatric disorders are quite common. Women have been shown to be more vulnerable to stress and are nearly twice as likely as men to develop stress-related disorders such as depression and anxi...

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Detalles Bibliográficos
Autor principal: Takahashi, Aki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921148/
https://www.ncbi.nlm.nih.gov/pubmed/33664686
http://dx.doi.org/10.3389/fpsyt.2021.644161
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author Takahashi, Aki
author_facet Takahashi, Aki
author_sort Takahashi, Aki
collection PubMed
description Significant sex differences in terms of prevalence, symptomatic profiles, severity, and comorbidities of psychiatric disorders are quite common. Women have been shown to be more vulnerable to stress and are nearly twice as likely as men to develop stress-related disorders such as depression and anxiety. Therefore, understanding sex differences with respect to the neurobiological mechanisms underlying stress-related disorders is important for developing more efficient pharmacological interventions for women. However, most preclinical studies on stress-related disorders have focused heavily on male rodents. Here, recent developments in the study of repeated social defeat stress models in female mice are summarized. Our findings suggest that a variety of factors need to be considered when employing this model.
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spelling pubmed-79211482021-03-03 Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models Takahashi, Aki Front Psychiatry Psychiatry Significant sex differences in terms of prevalence, symptomatic profiles, severity, and comorbidities of psychiatric disorders are quite common. Women have been shown to be more vulnerable to stress and are nearly twice as likely as men to develop stress-related disorders such as depression and anxiety. Therefore, understanding sex differences with respect to the neurobiological mechanisms underlying stress-related disorders is important for developing more efficient pharmacological interventions for women. However, most preclinical studies on stress-related disorders have focused heavily on male rodents. Here, recent developments in the study of repeated social defeat stress models in female mice are summarized. Our findings suggest that a variety of factors need to be considered when employing this model. Frontiers Media S.A. 2021-02-16 /pmc/articles/PMC7921148/ /pubmed/33664686 http://dx.doi.org/10.3389/fpsyt.2021.644161 Text en Copyright © 2021 Takahashi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Takahashi, Aki
Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models
title Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models
title_full Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models
title_fullStr Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models
title_full_unstemmed Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models
title_short Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models
title_sort toward understanding the sex differences in the biological mechanism of social stress in mouse models
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921148/
https://www.ncbi.nlm.nih.gov/pubmed/33664686
http://dx.doi.org/10.3389/fpsyt.2021.644161
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