A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation

The actin binding protein filamin A (FLNA) is required for somatostatin receptor 2 (SSTR2) and dopamine receptor 2 (DRD2) expression and signaling in GH- and PRL-secreting PitNETs, respectively, playing a role in tumor responsiveness to somatostatin receptors ligands and dopaminergic drugs. FLNA fun...

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Detalles Bibliográficos
Autores principales: Mangili, Federica, Treppiedi, Donatella, Catalano, Rosa, Marra, Giusy, Di Muro, Genesio, Spada, Anna, Arosio, Maura, Peverelli, Erika, Mantovani, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921166/
https://www.ncbi.nlm.nih.gov/pubmed/33664708
http://dx.doi.org/10.3389/fendo.2020.611752

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