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Prognostic value of miR-142 in solid tumors: a meta-analysis
Several studies on the prognostic value of microRNA 142 (miR-142) in solid tumors have reported conflicting results. Therefore, the aim of this meta-analysis was to evaluate the relationship between the miR-142 and prognosis in solid tumors. A comprehensive search for relevant studies was conducted...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921291/ https://www.ncbi.nlm.nih.gov/pubmed/33600577 http://dx.doi.org/10.1042/BSR20204043 |
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author | Liu, Rongqiang Zheng, Shiyang Yu, Kang Yu, Yajie Yu, Chenyu Shi, Wenqing Ge, Qianmin Ye, Zhiwei Shao, Yi |
author_facet | Liu, Rongqiang Zheng, Shiyang Yu, Kang Yu, Yajie Yu, Chenyu Shi, Wenqing Ge, Qianmin Ye, Zhiwei Shao, Yi |
author_sort | Liu, Rongqiang |
collection | PubMed |
description | Several studies on the prognostic value of microRNA 142 (miR-142) in solid tumors have reported conflicting results. Therefore, the aim of this meta-analysis was to evaluate the relationship between the miR-142 and prognosis in solid tumors. A comprehensive search for relevant studies was conducted until 10 November 2020. Studies that investigated the prognostic significance of the miR-142 in solid tumors were included. The hazard ratio and 95% confidence interval were calculated using a random-effects model. All data analyses were performed using the STATA 12.0 software (Stata Corporation, College Station, TX, U.S.A.). Twenty articles involving 2451 participants were included in the meta-analysis. The results showed that high miR-142 expression was a better predictor of overall survival (OS) (HR = 0.66, 95% CI: 0.47–0.93) and disease-free/progression-free/recurrence-free survival (DFS/PFS/RFS) (HR = 0.71, 95% CI: 0.55–0.91) compared with low miR-142 expression. MiR-142 can be used as an effective prognostic marker for patients with solid tumors. Future large prospective studies are warranted to further confirm the present findings. |
format | Online Article Text |
id | pubmed-7921291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79212912021-03-09 Prognostic value of miR-142 in solid tumors: a meta-analysis Liu, Rongqiang Zheng, Shiyang Yu, Kang Yu, Yajie Yu, Chenyu Shi, Wenqing Ge, Qianmin Ye, Zhiwei Shao, Yi Biosci Rep Cancer Several studies on the prognostic value of microRNA 142 (miR-142) in solid tumors have reported conflicting results. Therefore, the aim of this meta-analysis was to evaluate the relationship between the miR-142 and prognosis in solid tumors. A comprehensive search for relevant studies was conducted until 10 November 2020. Studies that investigated the prognostic significance of the miR-142 in solid tumors were included. The hazard ratio and 95% confidence interval were calculated using a random-effects model. All data analyses were performed using the STATA 12.0 software (Stata Corporation, College Station, TX, U.S.A.). Twenty articles involving 2451 participants were included in the meta-analysis. The results showed that high miR-142 expression was a better predictor of overall survival (OS) (HR = 0.66, 95% CI: 0.47–0.93) and disease-free/progression-free/recurrence-free survival (DFS/PFS/RFS) (HR = 0.71, 95% CI: 0.55–0.91) compared with low miR-142 expression. MiR-142 can be used as an effective prognostic marker for patients with solid tumors. Future large prospective studies are warranted to further confirm the present findings. Portland Press Ltd. 2021-02-26 /pmc/articles/PMC7921291/ /pubmed/33600577 http://dx.doi.org/10.1042/BSR20204043 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Cancer Liu, Rongqiang Zheng, Shiyang Yu, Kang Yu, Yajie Yu, Chenyu Shi, Wenqing Ge, Qianmin Ye, Zhiwei Shao, Yi Prognostic value of miR-142 in solid tumors: a meta-analysis |
title | Prognostic value of miR-142 in solid tumors: a meta-analysis |
title_full | Prognostic value of miR-142 in solid tumors: a meta-analysis |
title_fullStr | Prognostic value of miR-142 in solid tumors: a meta-analysis |
title_full_unstemmed | Prognostic value of miR-142 in solid tumors: a meta-analysis |
title_short | Prognostic value of miR-142 in solid tumors: a meta-analysis |
title_sort | prognostic value of mir-142 in solid tumors: a meta-analysis |
topic | Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921291/ https://www.ncbi.nlm.nih.gov/pubmed/33600577 http://dx.doi.org/10.1042/BSR20204043 |
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