Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells

The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for IESC maintenance, however, it remains unclear how this pathway selectively governs the identity and proliferative...

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Detalles Bibliográficos
Autores principales: Borrelli, Costanza, Valenta, Tomas, Handler, Kristina, Vélez, Karelia, Gurtner, Alessandra, Moro, Giulia, Lafzi, Atefeh, Roditi, Laura de Vargas, Hausmann, George, Arnold, Isabelle C., Moor, Andreas E., Basler, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921392/
https://www.ncbi.nlm.nih.gov/pubmed/33649334
http://dx.doi.org/10.1038/s41467-021-21591-9

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