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Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations
The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian and White populations. We analysed two population-based cohorts, composing of 1,221 Asians (SEED) and 703 White (WESDR) adults with diabetes. Retin...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921402/ https://www.ncbi.nlm.nih.gov/pubmed/33649427 http://dx.doi.org/10.1038/s41598-021-84464-7 |
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author | Nusinovici, Simon Sabanayagam, Charumathi Lee, Kristine E. Zhang, Liang Cheung, Carol Y. Tai, E. Shyong Tan, Gavin S. W. Cheng, Ching Yu Klein, Barbara E. K. Wong, Tien Yin |
author_facet | Nusinovici, Simon Sabanayagam, Charumathi Lee, Kristine E. Zhang, Liang Cheung, Carol Y. Tai, E. Shyong Tan, Gavin S. W. Cheng, Ching Yu Klein, Barbara E. K. Wong, Tien Yin |
author_sort | Nusinovici, Simon |
collection | PubMed |
description | The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian and White populations. We analysed two population-based cohorts, composing of 1,221 Asians (SEED) and 703 White (WESDR) adults with diabetes. Retinal microvascular signs at baseline included vascular caliber (arteriolar—CRAE, and venular—CRVE) and diabetic retinopathy (DR). Incident cases of DKD were identified after ~ 6-year. Incident cases were defined based on eGFR in SEED and proteinuria or history of renal dialysis in WESDR. The incidence of DKD were 11.8% in SEED and 14.0% in WESDR. Wider CRAE in SEED (OR = 1.58 [1.02, 2.45]) and wider CRVE (OR = 1.69 [1.02, 2.80)) in WESDR were associated with increased risk of DKD. Presence of DR was associated with an increased risk of DKD in both cohorts (SEED: OR = 1.91 [1.21, 3.01] in SEED, WESDR: OR = 1.99 [1.18, 3.35]). Adding DR and retinal vascular calibers in the model beyond traditional risk factors led to an improvement of predictive performance of DKD risk between 1.1 and 2.4%; and improved classification (NRI 3 between 9%). Microvascular changes in the retina are longitudinally associated with risk of DKD. |
format | Online Article Text |
id | pubmed-7921402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79214022021-03-02 Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations Nusinovici, Simon Sabanayagam, Charumathi Lee, Kristine E. Zhang, Liang Cheung, Carol Y. Tai, E. Shyong Tan, Gavin S. W. Cheng, Ching Yu Klein, Barbara E. K. Wong, Tien Yin Sci Rep Article The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian and White populations. We analysed two population-based cohorts, composing of 1,221 Asians (SEED) and 703 White (WESDR) adults with diabetes. Retinal microvascular signs at baseline included vascular caliber (arteriolar—CRAE, and venular—CRVE) and diabetic retinopathy (DR). Incident cases of DKD were identified after ~ 6-year. Incident cases were defined based on eGFR in SEED and proteinuria or history of renal dialysis in WESDR. The incidence of DKD were 11.8% in SEED and 14.0% in WESDR. Wider CRAE in SEED (OR = 1.58 [1.02, 2.45]) and wider CRVE (OR = 1.69 [1.02, 2.80)) in WESDR were associated with increased risk of DKD. Presence of DR was associated with an increased risk of DKD in both cohorts (SEED: OR = 1.91 [1.21, 3.01] in SEED, WESDR: OR = 1.99 [1.18, 3.35]). Adding DR and retinal vascular calibers in the model beyond traditional risk factors led to an improvement of predictive performance of DKD risk between 1.1 and 2.4%; and improved classification (NRI 3 between 9%). Microvascular changes in the retina are longitudinally associated with risk of DKD. Nature Publishing Group UK 2021-03-01 /pmc/articles/PMC7921402/ /pubmed/33649427 http://dx.doi.org/10.1038/s41598-021-84464-7 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Nusinovici, Simon Sabanayagam, Charumathi Lee, Kristine E. Zhang, Liang Cheung, Carol Y. Tai, E. Shyong Tan, Gavin S. W. Cheng, Ching Yu Klein, Barbara E. K. Wong, Tien Yin Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations |
title | Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations |
title_full | Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations |
title_fullStr | Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations |
title_full_unstemmed | Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations |
title_short | Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations |
title_sort | retinal microvascular signs and risk of diabetic kidney disease in asian and white populations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921402/ https://www.ncbi.nlm.nih.gov/pubmed/33649427 http://dx.doi.org/10.1038/s41598-021-84464-7 |
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