The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism

The Trial of Parkinson’s And Zoledronic acid (TOPAZ, https://clinicaltrials.gov/ct2/show/NCT03924414) is a unique collaboration between experts in movement disorders and osteoporosis to test the efficacy of zoledronic acid, an FDA-approved parenteral treatment for osteoporosis, for fracture preventi...

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Autores principales: Tanner, Caroline M., Cummings, Steven R., Schwarzschild, Michael A., Brown, Ethan G., Dorsey, E. Ray, Espay, Alberto J., Galifianakis, Nicholas B., Goldman, Samuel M., Litvan, Irene, Luthra, Nijee, McFarland, Nikolaus R., Mitchell, Kyle T., Standaert, David G., Bauer, Douglas C., Greenspan, Susan L., Beck, James C., Lyles, Kenneth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921548/
https://www.ncbi.nlm.nih.gov/pubmed/33649343
http://dx.doi.org/10.1038/s41531-021-00162-1
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author Tanner, Caroline M.
Cummings, Steven R.
Schwarzschild, Michael A.
Brown, Ethan G.
Dorsey, E. Ray
Espay, Alberto J.
Galifianakis, Nicholas B.
Goldman, Samuel M.
Litvan, Irene
Luthra, Nijee
McFarland, Nikolaus R.
Mitchell, Kyle T.
Standaert, David G.
Bauer, Douglas C.
Greenspan, Susan L.
Beck, James C.
Lyles, Kenneth W.
author_facet Tanner, Caroline M.
Cummings, Steven R.
Schwarzschild, Michael A.
Brown, Ethan G.
Dorsey, E. Ray
Espay, Alberto J.
Galifianakis, Nicholas B.
Goldman, Samuel M.
Litvan, Irene
Luthra, Nijee
McFarland, Nikolaus R.
Mitchell, Kyle T.
Standaert, David G.
Bauer, Douglas C.
Greenspan, Susan L.
Beck, James C.
Lyles, Kenneth W.
author_sort Tanner, Caroline M.
collection PubMed
description The Trial of Parkinson’s And Zoledronic acid (TOPAZ, https://clinicaltrials.gov/ct2/show/NCT03924414) is a unique collaboration between experts in movement disorders and osteoporosis to test the efficacy of zoledronic acid, an FDA-approved parenteral treatment for osteoporosis, for fracture prevention in people with neurodegenerative parkinsonism. Aiming to enroll 3,500 participants age 65 years or older, TOPAZ is one of the largest randomized, placebo-controlled clinical trials ever attempted in parkinsonism. The feasibility of TOPAZ is enhanced by its design as a U.S.- wide home-based trial without geographical limits. Participants receive information from multiple sources, including specialty practices, support groups and websites. Conducting TOPAZ in participants’ homes takes advantage of online consent technology, the capacity to confirm diagnosis using telemedicine and the availability of research nursing to provide screening and parenteral therapy in homes. Home-based clinical research may provide an efficient, convenient, less expensive method that opens participation in clinical trials to almost anyone with parkinsonism.
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spelling pubmed-79215482021-03-12 The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism Tanner, Caroline M. Cummings, Steven R. Schwarzschild, Michael A. Brown, Ethan G. Dorsey, E. Ray Espay, Alberto J. Galifianakis, Nicholas B. Goldman, Samuel M. Litvan, Irene Luthra, Nijee McFarland, Nikolaus R. Mitchell, Kyle T. Standaert, David G. Bauer, Douglas C. Greenspan, Susan L. Beck, James C. Lyles, Kenneth W. NPJ Parkinsons Dis Article The Trial of Parkinson’s And Zoledronic acid (TOPAZ, https://clinicaltrials.gov/ct2/show/NCT03924414) is a unique collaboration between experts in movement disorders and osteoporosis to test the efficacy of zoledronic acid, an FDA-approved parenteral treatment for osteoporosis, for fracture prevention in people with neurodegenerative parkinsonism. Aiming to enroll 3,500 participants age 65 years or older, TOPAZ is one of the largest randomized, placebo-controlled clinical trials ever attempted in parkinsonism. The feasibility of TOPAZ is enhanced by its design as a U.S.- wide home-based trial without geographical limits. Participants receive information from multiple sources, including specialty practices, support groups and websites. Conducting TOPAZ in participants’ homes takes advantage of online consent technology, the capacity to confirm diagnosis using telemedicine and the availability of research nursing to provide screening and parenteral therapy in homes. Home-based clinical research may provide an efficient, convenient, less expensive method that opens participation in clinical trials to almost anyone with parkinsonism. Nature Publishing Group UK 2021-03-01 /pmc/articles/PMC7921548/ /pubmed/33649343 http://dx.doi.org/10.1038/s41531-021-00162-1 Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tanner, Caroline M.
Cummings, Steven R.
Schwarzschild, Michael A.
Brown, Ethan G.
Dorsey, E. Ray
Espay, Alberto J.
Galifianakis, Nicholas B.
Goldman, Samuel M.
Litvan, Irene
Luthra, Nijee
McFarland, Nikolaus R.
Mitchell, Kyle T.
Standaert, David G.
Bauer, Douglas C.
Greenspan, Susan L.
Beck, James C.
Lyles, Kenneth W.
The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism
title The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism
title_full The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism
title_fullStr The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism
title_full_unstemmed The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism
title_short The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism
title_sort topaz study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921548/
https://www.ncbi.nlm.nih.gov/pubmed/33649343
http://dx.doi.org/10.1038/s41531-021-00162-1
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