Nintedanib promotes antitumour immunity and shows antitumour activity in combination with PD-1 blockade in mice: potential role of cancer-associated fibroblasts

BACKGROUND: Cancer-associated fibroblasts (CAFs) in the tumour microenvironment (TME) suppress antitumour immunity, and the tyrosine kinase inhibitor nintedanib has antifibrotic effects. METHODS: We performed a preclinical study to evaluate whether nintedanib might enhance antitumour immunity by tar...

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Detalles Bibliográficos
Autores principales: Kato, Ryoji, Haratani, Koji, Hayashi, Hidetoshi, Sakai, Kazuko, Sakai, Hitomi, Kawakami, Hisato, Tanaka, Kaoru, Takeda, Masayuki, Yonesaka, Kimio, Nishio, Kazuto, Nakagawa, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921555/
https://www.ncbi.nlm.nih.gov/pubmed/33299131
http://dx.doi.org/10.1038/s41416-020-01201-z

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