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Engineered models of tumor metastasis with immune cell contributions

Most cancer deaths are due to tumor metastasis rather than the primary tumor. Metastasis is a highly complex and dynamic process that requires orchestration of signaling between the tumor, its local environment, distant tissue sites, and immune system. Animal models of cancer metastasis provide the...

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Autores principales: Graney, Pamela L., Tavakol, Daniel Naveed, Chramiec, Alan, Ronaldson-Bouchard, Kacey, Vunjak-Novakovic, Gordana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921600/
https://www.ncbi.nlm.nih.gov/pubmed/33718831
http://dx.doi.org/10.1016/j.isci.2021.102179
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author Graney, Pamela L.
Tavakol, Daniel Naveed
Chramiec, Alan
Ronaldson-Bouchard, Kacey
Vunjak-Novakovic, Gordana
author_facet Graney, Pamela L.
Tavakol, Daniel Naveed
Chramiec, Alan
Ronaldson-Bouchard, Kacey
Vunjak-Novakovic, Gordana
author_sort Graney, Pamela L.
collection PubMed
description Most cancer deaths are due to tumor metastasis rather than the primary tumor. Metastasis is a highly complex and dynamic process that requires orchestration of signaling between the tumor, its local environment, distant tissue sites, and immune system. Animal models of cancer metastasis provide the necessary systemic environment but lack control over factors that regulate cancer progression and often do not recapitulate the properties of human cancers. Bioengineered “organs-on-a-chip” that incorporate the primary tumor, metastatic tissue targets, and microfluidic perfusion are now emerging as quantitative human models of tumor metastasis. The ability of these systems to model tumor metastasis in individualized, patient-specific settings makes them uniquely suitable for studies of cancer biology and developmental testing of new treatments. In this review, we focus on human multi-organ platforms that incorporate circulating and tissue-resident immune cells in studies of tumor metastasis.
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spelling pubmed-79216002021-03-12 Engineered models of tumor metastasis with immune cell contributions Graney, Pamela L. Tavakol, Daniel Naveed Chramiec, Alan Ronaldson-Bouchard, Kacey Vunjak-Novakovic, Gordana iScience Review Most cancer deaths are due to tumor metastasis rather than the primary tumor. Metastasis is a highly complex and dynamic process that requires orchestration of signaling between the tumor, its local environment, distant tissue sites, and immune system. Animal models of cancer metastasis provide the necessary systemic environment but lack control over factors that regulate cancer progression and often do not recapitulate the properties of human cancers. Bioengineered “organs-on-a-chip” that incorporate the primary tumor, metastatic tissue targets, and microfluidic perfusion are now emerging as quantitative human models of tumor metastasis. The ability of these systems to model tumor metastasis in individualized, patient-specific settings makes them uniquely suitable for studies of cancer biology and developmental testing of new treatments. In this review, we focus on human multi-organ platforms that incorporate circulating and tissue-resident immune cells in studies of tumor metastasis. Elsevier 2021-02-12 /pmc/articles/PMC7921600/ /pubmed/33718831 http://dx.doi.org/10.1016/j.isci.2021.102179 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Graney, Pamela L.
Tavakol, Daniel Naveed
Chramiec, Alan
Ronaldson-Bouchard, Kacey
Vunjak-Novakovic, Gordana
Engineered models of tumor metastasis with immune cell contributions
title Engineered models of tumor metastasis with immune cell contributions
title_full Engineered models of tumor metastasis with immune cell contributions
title_fullStr Engineered models of tumor metastasis with immune cell contributions
title_full_unstemmed Engineered models of tumor metastasis with immune cell contributions
title_short Engineered models of tumor metastasis with immune cell contributions
title_sort engineered models of tumor metastasis with immune cell contributions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921600/
https://www.ncbi.nlm.nih.gov/pubmed/33718831
http://dx.doi.org/10.1016/j.isci.2021.102179
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