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Engineered models of tumor metastasis with immune cell contributions
Most cancer deaths are due to tumor metastasis rather than the primary tumor. Metastasis is a highly complex and dynamic process that requires orchestration of signaling between the tumor, its local environment, distant tissue sites, and immune system. Animal models of cancer metastasis provide the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921600/ https://www.ncbi.nlm.nih.gov/pubmed/33718831 http://dx.doi.org/10.1016/j.isci.2021.102179 |
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author | Graney, Pamela L. Tavakol, Daniel Naveed Chramiec, Alan Ronaldson-Bouchard, Kacey Vunjak-Novakovic, Gordana |
author_facet | Graney, Pamela L. Tavakol, Daniel Naveed Chramiec, Alan Ronaldson-Bouchard, Kacey Vunjak-Novakovic, Gordana |
author_sort | Graney, Pamela L. |
collection | PubMed |
description | Most cancer deaths are due to tumor metastasis rather than the primary tumor. Metastasis is a highly complex and dynamic process that requires orchestration of signaling between the tumor, its local environment, distant tissue sites, and immune system. Animal models of cancer metastasis provide the necessary systemic environment but lack control over factors that regulate cancer progression and often do not recapitulate the properties of human cancers. Bioengineered “organs-on-a-chip” that incorporate the primary tumor, metastatic tissue targets, and microfluidic perfusion are now emerging as quantitative human models of tumor metastasis. The ability of these systems to model tumor metastasis in individualized, patient-specific settings makes them uniquely suitable for studies of cancer biology and developmental testing of new treatments. In this review, we focus on human multi-organ platforms that incorporate circulating and tissue-resident immune cells in studies of tumor metastasis. |
format | Online Article Text |
id | pubmed-7921600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-79216002021-03-12 Engineered models of tumor metastasis with immune cell contributions Graney, Pamela L. Tavakol, Daniel Naveed Chramiec, Alan Ronaldson-Bouchard, Kacey Vunjak-Novakovic, Gordana iScience Review Most cancer deaths are due to tumor metastasis rather than the primary tumor. Metastasis is a highly complex and dynamic process that requires orchestration of signaling between the tumor, its local environment, distant tissue sites, and immune system. Animal models of cancer metastasis provide the necessary systemic environment but lack control over factors that regulate cancer progression and often do not recapitulate the properties of human cancers. Bioengineered “organs-on-a-chip” that incorporate the primary tumor, metastatic tissue targets, and microfluidic perfusion are now emerging as quantitative human models of tumor metastasis. The ability of these systems to model tumor metastasis in individualized, patient-specific settings makes them uniquely suitable for studies of cancer biology and developmental testing of new treatments. In this review, we focus on human multi-organ platforms that incorporate circulating and tissue-resident immune cells in studies of tumor metastasis. Elsevier 2021-02-12 /pmc/articles/PMC7921600/ /pubmed/33718831 http://dx.doi.org/10.1016/j.isci.2021.102179 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Graney, Pamela L. Tavakol, Daniel Naveed Chramiec, Alan Ronaldson-Bouchard, Kacey Vunjak-Novakovic, Gordana Engineered models of tumor metastasis with immune cell contributions |
title | Engineered models of tumor metastasis with immune cell contributions |
title_full | Engineered models of tumor metastasis with immune cell contributions |
title_fullStr | Engineered models of tumor metastasis with immune cell contributions |
title_full_unstemmed | Engineered models of tumor metastasis with immune cell contributions |
title_short | Engineered models of tumor metastasis with immune cell contributions |
title_sort | engineered models of tumor metastasis with immune cell contributions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921600/ https://www.ncbi.nlm.nih.gov/pubmed/33718831 http://dx.doi.org/10.1016/j.isci.2021.102179 |
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