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A versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses
A novel, integrated, in vitro gastrointestinal (GI) system is presented to study oral bioavailability parameters of small molecules. Three compartments were combined into one hyphenated, flow-through set-up. In the first compartment, a compound was exposed dynamically to enzymatic digestion in three...
Autores principales: | de Haan, Pim, Santbergen, Milou J. C., van der Zande, Meike, Bouwmeester, Hans, Nielen, Michel W. F., Verpoorte, Elisabeth |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921645/ https://www.ncbi.nlm.nih.gov/pubmed/33649376 http://dx.doi.org/10.1038/s41598-021-84187-9 |
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