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FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence, and drug resistance are the main causes to cripples and deaths of OSCC patients. As potent growth factors, fibroblast growth factors (FGFs) are freque...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921665/ https://www.ncbi.nlm.nih.gov/pubmed/33649301 http://dx.doi.org/10.1038/s41368-021-00111-x |
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author | Hao, Yilong Xiao, Yanxuan Liao, Xiaoyu Tang, Shuya Xie, Xiaoyan Liu, Rui Chen, Qianming |
author_facet | Hao, Yilong Xiao, Yanxuan Liao, Xiaoyu Tang, Shuya Xie, Xiaoyan Liu, Rui Chen, Qianming |
author_sort | Hao, Yilong |
collection | PubMed |
description | Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence, and drug resistance are the main causes to cripples and deaths of OSCC patients. As potent growth factors, fibroblast growth factors (FGFs) are frequently susceptible to being hijacked by cancer cells. In this study, we show that FGF8 is upregulated in OSCC tissues and high FGF8 expression is related with a set of clinicopathologic parameters, including age, drinking, and survival time. FGF8 treatment enhances the invasive capability of OSCC cells. Lentivirus-based FGF8 expression promotes OSCC metastasis in a mouse lung metastasis model. Further, mechanistic study demonstrates that FGF8 induces epithelial–mesenchymal transition (EMT) in OSCC cells. These results highlight a pro-metastatic function of FGF8, and underscore the role of FGF8 in OSCC development. |
format | Online Article Text |
id | pubmed-7921665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79216652021-03-12 FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma Hao, Yilong Xiao, Yanxuan Liao, Xiaoyu Tang, Shuya Xie, Xiaoyan Liu, Rui Chen, Qianming Int J Oral Sci Article Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence, and drug resistance are the main causes to cripples and deaths of OSCC patients. As potent growth factors, fibroblast growth factors (FGFs) are frequently susceptible to being hijacked by cancer cells. In this study, we show that FGF8 is upregulated in OSCC tissues and high FGF8 expression is related with a set of clinicopathologic parameters, including age, drinking, and survival time. FGF8 treatment enhances the invasive capability of OSCC cells. Lentivirus-based FGF8 expression promotes OSCC metastasis in a mouse lung metastasis model. Further, mechanistic study demonstrates that FGF8 induces epithelial–mesenchymal transition (EMT) in OSCC cells. These results highlight a pro-metastatic function of FGF8, and underscore the role of FGF8 in OSCC development. Nature Publishing Group UK 2021-03-01 /pmc/articles/PMC7921665/ /pubmed/33649301 http://dx.doi.org/10.1038/s41368-021-00111-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hao, Yilong Xiao, Yanxuan Liao, Xiaoyu Tang, Shuya Xie, Xiaoyan Liu, Rui Chen, Qianming FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma |
title | FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma |
title_full | FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma |
title_fullStr | FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma |
title_full_unstemmed | FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma |
title_short | FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma |
title_sort | fgf8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921665/ https://www.ncbi.nlm.nih.gov/pubmed/33649301 http://dx.doi.org/10.1038/s41368-021-00111-x |
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