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Chemogenetic ON and OFF switches for RNA virus replication

Therapeutic application of RNA viruses as oncolytic agents or gene vectors requires a tight control of virus activity if toxicity is a concern. Here we present a regulator switch for RNA viruses using a conditional protease approach, in which the function of at least one viral protein essential for...

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Detalles Bibliográficos
Autores principales:	Heilmann, E., Kimpel, J., Hofer, B., Rössler, A., Blaas, I., Egerer, L., Nolden, T., Urbiola, C., Kräusslich, H. G., Wollmann, G., von Laer, D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921684/ https://www.ncbi.nlm.nih.gov/pubmed/33649317 http://dx.doi.org/10.1038/s41467-021-21630-5

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