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Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine

Traditional Chinese medicine (TCM) was the primary source of medical treatment for the people inhabiting East Asia for thousands of years. These ancient practices have incorporated a wide variety of materia medica including plants, animals and minerals. As modern sciences, including natural products...

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Autores principales: Deyrup, Stephen T., Stagnitti, Natalie C., Perpetua, Mackenzie J., Wong-Deyrup, Siu Wah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921859/
https://www.ncbi.nlm.nih.gov/pubmed/33632986
http://dx.doi.org/10.4062/biomolther.2020.229
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author Deyrup, Stephen T.
Stagnitti, Natalie C.
Perpetua, Mackenzie J.
Wong-Deyrup, Siu Wah
author_facet Deyrup, Stephen T.
Stagnitti, Natalie C.
Perpetua, Mackenzie J.
Wong-Deyrup, Siu Wah
author_sort Deyrup, Stephen T.
collection PubMed
description Traditional Chinese medicine (TCM) was the primary source of medical treatment for the people inhabiting East Asia for thousands of years. These ancient practices have incorporated a wide variety of materia medica including plants, animals and minerals. As modern sciences, including natural products chemistry, emerged, there became increasing efforts to explore the chemistry of this materia medica to find molecules responsible for their traditional use. Insects, including beetles have played an important role in TCM. In our survey of texts and review articles on TCM materia medica, we found 48 species of beetles from 34 genera in 14 different families that are used in TCM. This review covers the chemistry known from the beetles used in TCM, or in cases where a species used in these practices has not been chemically studied, we discuss the chemistry of closely related beetles. We also found several documented uses of beetles in Traditional Korean Medicine (TKM), and included them where appropriate. There are 129 chemical constituents of beetles discussed.
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spelling pubmed-79218592021-03-02 Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine Deyrup, Stephen T. Stagnitti, Natalie C. Perpetua, Mackenzie J. Wong-Deyrup, Siu Wah Biomol Ther (Seoul) Review Traditional Chinese medicine (TCM) was the primary source of medical treatment for the people inhabiting East Asia for thousands of years. These ancient practices have incorporated a wide variety of materia medica including plants, animals and minerals. As modern sciences, including natural products chemistry, emerged, there became increasing efforts to explore the chemistry of this materia medica to find molecules responsible for their traditional use. Insects, including beetles have played an important role in TCM. In our survey of texts and review articles on TCM materia medica, we found 48 species of beetles from 34 genera in 14 different families that are used in TCM. This review covers the chemistry known from the beetles used in TCM, or in cases where a species used in these practices has not been chemically studied, we discuss the chemistry of closely related beetles. We also found several documented uses of beetles in Traditional Korean Medicine (TKM), and included them where appropriate. There are 129 chemical constituents of beetles discussed. The Korean Society of Applied Pharmacology 2021-03-01 2021-03-01 /pmc/articles/PMC7921859/ /pubmed/33632986 http://dx.doi.org/10.4062/biomolther.2020.229 Text en Copyright © 2021, The Korean Society of Applied Pharmacology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Deyrup, Stephen T.
Stagnitti, Natalie C.
Perpetua, Mackenzie J.
Wong-Deyrup, Siu Wah
Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine
title Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine
title_full Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine
title_fullStr Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine
title_full_unstemmed Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine
title_short Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine
title_sort drug discovery insights from medicinal beetles in traditional chinese medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921859/
https://www.ncbi.nlm.nih.gov/pubmed/33632986
http://dx.doi.org/10.4062/biomolther.2020.229
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