Cargando…

Effect of Oxaliplatin, Olaparib and LY294002 in Combination on Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) has a poor prognosis as the therapy has several limitations, most importantly, treatment resistance. In this study we examined the different responses of triple-negative breast cancer line MDA-MB-231 and hormone receptor-positive breast cancer line MCF7 to a comb...

Descripción completa

Detalles Bibliográficos
Autores principales:	Andreidesz, Kitti, Koszegi, Balazs, Kovacs, Dominika, Bagone Vantus, Viola, Gallyas, Ferenc, Kovacs, Krisztina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921931/ https://www.ncbi.nlm.nih.gov/pubmed/33669671 http://dx.doi.org/10.3390/ijms22042056

Ejemplares similares

Cytostatic Effect of a Novel Mitochondria-Targeted Pyrroline Nitroxide in Human Breast Cancer Lines
por: Andreidesz, Kitti, et al.
Publicado: (2021)

Olaparib: A Clinically Applied PARP Inhibitor Protects from Experimental Crohn's Disease and Maintains Barrier Integrity by Improving Bioenergetics through Rescuing Glycolysis in Colonic Epithelial Cells
por: Kovács, Dominika, et al.
Publicado: (2021)

Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming
por: Vámos, Eszter, et al.
Publicado: (2023)

Synergistic Lethality of Mifepristone and LY294002 in Ovarian Cancer Cells
por: Wempe, Stacy L., et al.
Publicado: (2013)

LY-294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K/AKT/HIF-1α pathway
por: Xu, Ruyue, et al.
Publicado: (2021)

Combined low-dose LiCl and LY294002 for the treatment of osteoporosis in ovariectomized rats
por: Bai, Jianhai, et al.
Publicado: (2019)

Involvement of Mitochondrial Mechanisms and Cyclooxygenase-2 Activation in the Effect of Desethylamiodarone on 4T1 Triple-Negative Breast Cancer Line
por: Gallyas, Ferenc, et al.
Publicado: (2022)

LY294002 alleviates bone cancer pain by reducing mitochondrial dysfunction and the inflammatory response
por: Zhao, Jiajia, et al.
Publicado: (2023)

Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice
por: Garai, János, et al.
Publicado: (2021)

Novel Mechanisms of Sildenafil in Pulmonary Hypertension Involving Cytokines/Chemokines, MAP Kinases and Akt
por: Kiss, Tamas, et al.
Publicado: (2014)

Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells
por: Fujiwara, Masao, et al.
Publicado: (2008)

Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo
por: Jiang, Hanguo, et al.
Publicado: (2010)

LY294002 induces differentiation and inhibits invasion of glioblastoma cells by targeting GSK-3beta and MMP
por: Tian, Qi, et al.
Publicado: (2012)

LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2
por: Lu, Jian, et al.
Publicado: (2018)

Modulation of Mitochondrial Quality Control Processes by BGP-15 in Oxidative Stress Scenarios: From Cell Culture to Heart Failure
por: Horvath, Orsolya, et al.
Publicado: (2021)

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death
por: A, Zając, et al.
Publicado: (2021)

Reversion of glucocorticoid-induced senescence and collagen synthesis decrease by LY294002 is mediated through p38 in skin
por: Le, Quoc-Vu, et al.
Publicado: (2022)

SN50 enhances the effects of LY294002 on cell death induction in gastric cancer cell line SGC7901
por: Zhao, Kui, et al.
Publicado: (2013)

LY294002 Inhibits Intermediate Conductance Calcium-Activated Potassium (KCa3.1) Current in Human Glioblastoma Cells
por: Caglioti, Concetta, et al.
Publicado: (2022)

Encapsulation of PI3K Inhibitor LY294002 within Polymer Nanoparticles Using Ion Pairing Flash Nanoprecipitation
por: Fergusson, Austin D., et al.
Publicado: (2023)

LY 294002 inhibits adenosine receptor activation by a mechanism independent of effects on PI-3 kinase or casein kinase II
por: Searl, T. J., et al.
Publicado: (2005)

Autophagy Inhibitor (LY294002) and 5-fluorouracil (5-FU) Combination-Based Nanoliposome for Enhanced Efficacy Against Esophageal Squamous Cell Carcinoma
por: Feng, Ye, et al.
Publicado: (2018)

Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells
por: Linero, Florencia N., et al.
Publicado: (2014)

Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002
por: Cai, Xinyi, et al.
Publicado: (2015)

Tamoxifen and the PI3K Inhibitor: LY294002 Synergistically Induce Apoptosis and Cell Cycle Arrest in Breast Cancer MCF-7 Cells
por: Abdallah, Mohamed E., et al.
Publicado: (2020)

Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer
por: Jang, Na Young, et al.
Publicado: (2015)

Versatile inhibitory effects of the flavonoid-derived PI3K/Akt inhibitor, LY294002, on ATP-binding cassette transporters that characterize stem cells
por: Imai, Yasuo, et al.
Publicado: (2012)

LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells
por: Shin, Jung-Young, et al.
Publicado: (2010)

The Role of the LY294002 - A Non-Selective Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) Pathway- in Cell Survival and Proliferation in Cell Line SCC-25
por: Duarte, Andressa, et al.
Publicado: (2019)

LY294002 Is a Promising Inhibitor to Overcome Sorafenib Resistance in FLT3-ITD Mutant AML Cells by Interfering With PI3K/Akt Signaling Pathway
por: Huang, Amin, et al.
Publicado: (2021)

Distinct Uptake Routes Participate in Silver Nanoparticle Engulfment by Earthworm and Human Immune Cells
por: Kokhanyuk, Bohdana, et al.
Publicado: (2022)

Phase I/Ib study of olaparib and carboplatin in women with triple negative breast cancer
por: Lee, Jung-Min, et al.
Publicado: (2017)

Involvement of Mitochondrial Mechanisms in the Cytostatic Effect of Desethylamiodarone in B16F10 Melanoma Cells
por: Ramadan, Fadi H. J., et al.
Publicado: (2020)

Antitumor effects and mechanisms of olaparib in combination with carboplatin and BKM120 on human triple-negative breast cancer cells
por: Zhao, Hui, et al.
Publicado: (2018)

Analysis of Adaptive Olaparib Resistance Effects on Cisplatin Sensitivity in Triple Negative Breast Cancer Cells
por: Gajan, Ambikai, et al.
Publicado: (2021)

Inhibition of APE1 Expression Enhances the Antitumor Activity of Olaparib in Triple-Negative Breast Cancer
por: Jian, Dan, et al.
Publicado: (2022)

BGP-15 Protects against Heart Failure by Enhanced Mitochondrial Biogenesis and Decreased Fibrotic Remodelling in Spontaneously Hypertensive Rats
por: Horvath, Orsolya, et al.
Publicado: (2021)

Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells
por: Mani, Chinnadurai, et al.
Publicado: (2019)

PRMT1 Confers Resistance to Olaparib via Modulating MYC Signaling in Triple-Negative Breast Cancer
por: Hsu, Wen-Jing, et al.
Publicado: (2021)

The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc
por: Hegedüs, Imre, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g4tulvr9206tv1fnjjenq69mql