The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology

This review describes the history of alcoholic liver disease from the beginning of the 1950s until now. It details how the hepatotoxicity of alcohol was discovered by epidemiology and basic research primarily by using new feeding techniques in rodents and primates. The article also recognizes the pi...

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Detalles Bibliográficos
Autores principales: Seitz, Helmut K., Neuman, Manuela G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921942/
https://www.ncbi.nlm.nih.gov/pubmed/33669694
http://dx.doi.org/10.3390/jcm10040858
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author Seitz, Helmut K.
Neuman, Manuela G.
author_facet Seitz, Helmut K.
Neuman, Manuela G.
author_sort Seitz, Helmut K.
collection PubMed
description This review describes the history of alcoholic liver disease from the beginning of the 1950s until now. It details how the hepatotoxicity of alcohol was discovered by epidemiology and basic research primarily by using new feeding techniques in rodents and primates. The article also recognizes the pioneering work of scientists who contributed to the understanding of the pathophysiology of alcoholic liver disease. In addition, clinical aspects, such as the development of diagnostics and treatment options for alcoholic liver disease, are discussed. Up-to-date knowledge of the mechanism of the disease in 2020 is presented.
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spelling pubmed-79219422021-03-03 The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology Seitz, Helmut K. Neuman, Manuela G. J Clin Med Review This review describes the history of alcoholic liver disease from the beginning of the 1950s until now. It details how the hepatotoxicity of alcohol was discovered by epidemiology and basic research primarily by using new feeding techniques in rodents and primates. The article also recognizes the pioneering work of scientists who contributed to the understanding of the pathophysiology of alcoholic liver disease. In addition, clinical aspects, such as the development of diagnostics and treatment options for alcoholic liver disease, are discussed. Up-to-date knowledge of the mechanism of the disease in 2020 is presented. MDPI 2021-02-19 /pmc/articles/PMC7921942/ /pubmed/33669694 http://dx.doi.org/10.3390/jcm10040858 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Seitz, Helmut K.
Neuman, Manuela G.
The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology
title The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology
title_full The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology
title_fullStr The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology
title_full_unstemmed The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology
title_short The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology
title_sort history of alcoholic liver disease: from an unrecognized disease to one of the most frequent diseases in hepatology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921942/
https://www.ncbi.nlm.nih.gov/pubmed/33669694
http://dx.doi.org/10.3390/jcm10040858
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