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Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways

Syzygium fruticosum (SF), a valuable Bangladeshi fruit, is considered an alternative therapeutic agent. Mainly, seeds are used as nutritional phytotherapy to ease physical and mental status by preventing chronic diseases. Here, we scrutinized the S. fruticosum seed’s fundamental importance in tradit...

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Autores principales: Moni, Jannatul Nasma Rupa, Adnan, Md., Tareq, Abu Montakim, Kabir, Md. Imtiazul, Reza, A.S.M. Ali, Nasrin, Mst. Samima, Chowdhury, Kamrul Hasan, Sayem, Syed Al Jawad, Rahman, Md Atiar, Alam, AHM Khurshid, Alam, Seema Binte, Sakib, Mahfuz Ahmed, Oh, Ki Kwang, Cho, Dong Ha, Capasso, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921944/
https://www.ncbi.nlm.nih.gov/pubmed/33671381
http://dx.doi.org/10.3390/life11020155
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author Moni, Jannatul Nasma Rupa
Adnan, Md.
Tareq, Abu Montakim
Kabir, Md. Imtiazul
Reza, A.S.M. Ali
Nasrin, Mst. Samima
Chowdhury, Kamrul Hasan
Sayem, Syed Al Jawad
Rahman, Md Atiar
Alam, AHM Khurshid
Alam, Seema Binte
Sakib, Mahfuz Ahmed
Oh, Ki Kwang
Cho, Dong Ha
Capasso, Raffaele
author_facet Moni, Jannatul Nasma Rupa
Adnan, Md.
Tareq, Abu Montakim
Kabir, Md. Imtiazul
Reza, A.S.M. Ali
Nasrin, Mst. Samima
Chowdhury, Kamrul Hasan
Sayem, Syed Al Jawad
Rahman, Md Atiar
Alam, AHM Khurshid
Alam, Seema Binte
Sakib, Mahfuz Ahmed
Oh, Ki Kwang
Cho, Dong Ha
Capasso, Raffaele
author_sort Moni, Jannatul Nasma Rupa
collection PubMed
description Syzygium fruticosum (SF), a valuable Bangladeshi fruit, is considered an alternative therapeutic agent. Mainly, seeds are used as nutritional phytotherapy to ease physical and mental status by preventing chronic diseases. Here, we scrutinized the S. fruticosum seed’s fundamental importance in traditional medicine by following an integrated approach combining in vivo, in vitro, and in silico studies. The SF was fractionated with different solvents, and the ethyl acetate fraction of SF (EaF-SF) was further studied. Mice treated with EaF-SF (200 and 400 mg/kg) manifested anxiolysis evidenced by higher exploration in elevated plus maze and hole board tests. Similarly, a dose-dependent drop of immobility time in a forced swimming test ensured significant anti-depressant activity. Moreover, higher dose treatment exposed reduced exploratory behaviour resembling decreased movement and prolonged sleeping latency with a quick onset of sleep during the open field and thiopental-induced sleeping tests, respectively. In parallel, EaF-SF significantly (p < 0.001) and dose-dependently suppressed acetic acid and formalin-induced pain in mice. Also, a noteworthy anti-inflammatory activity and a substantial (p < 0.01) clot lysis activity (thrombolytic) was observed. Gas chromatography-mass spectrometry (GC–MS) analysis resulted in 49 bioactive compounds. Among them, 12 bioactive compounds with Lipinski’s rule and safety confirmation showed strong binding affinity (molecular docking) against the receptors of each model used. To conclude, the S. fruticosum seed is a prospective source of health-promoting effects that can be an excellent candidate for preventing degenerative diseases.
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spelling pubmed-79219442021-03-03 Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways Moni, Jannatul Nasma Rupa Adnan, Md. Tareq, Abu Montakim Kabir, Md. Imtiazul Reza, A.S.M. Ali Nasrin, Mst. Samima Chowdhury, Kamrul Hasan Sayem, Syed Al Jawad Rahman, Md Atiar Alam, AHM Khurshid Alam, Seema Binte Sakib, Mahfuz Ahmed Oh, Ki Kwang Cho, Dong Ha Capasso, Raffaele Life (Basel) Article Syzygium fruticosum (SF), a valuable Bangladeshi fruit, is considered an alternative therapeutic agent. Mainly, seeds are used as nutritional phytotherapy to ease physical and mental status by preventing chronic diseases. Here, we scrutinized the S. fruticosum seed’s fundamental importance in traditional medicine by following an integrated approach combining in vivo, in vitro, and in silico studies. The SF was fractionated with different solvents, and the ethyl acetate fraction of SF (EaF-SF) was further studied. Mice treated with EaF-SF (200 and 400 mg/kg) manifested anxiolysis evidenced by higher exploration in elevated plus maze and hole board tests. Similarly, a dose-dependent drop of immobility time in a forced swimming test ensured significant anti-depressant activity. Moreover, higher dose treatment exposed reduced exploratory behaviour resembling decreased movement and prolonged sleeping latency with a quick onset of sleep during the open field and thiopental-induced sleeping tests, respectively. In parallel, EaF-SF significantly (p < 0.001) and dose-dependently suppressed acetic acid and formalin-induced pain in mice. Also, a noteworthy anti-inflammatory activity and a substantial (p < 0.01) clot lysis activity (thrombolytic) was observed. Gas chromatography-mass spectrometry (GC–MS) analysis resulted in 49 bioactive compounds. Among them, 12 bioactive compounds with Lipinski’s rule and safety confirmation showed strong binding affinity (molecular docking) against the receptors of each model used. To conclude, the S. fruticosum seed is a prospective source of health-promoting effects that can be an excellent candidate for preventing degenerative diseases. MDPI 2021-02-17 /pmc/articles/PMC7921944/ /pubmed/33671381 http://dx.doi.org/10.3390/life11020155 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moni, Jannatul Nasma Rupa
Adnan, Md.
Tareq, Abu Montakim
Kabir, Md. Imtiazul
Reza, A.S.M. Ali
Nasrin, Mst. Samima
Chowdhury, Kamrul Hasan
Sayem, Syed Al Jawad
Rahman, Md Atiar
Alam, AHM Khurshid
Alam, Seema Binte
Sakib, Mahfuz Ahmed
Oh, Ki Kwang
Cho, Dong Ha
Capasso, Raffaele
Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways
title Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways
title_full Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways
title_fullStr Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways
title_full_unstemmed Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways
title_short Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways
title_sort therapeutic potentials of syzygium fruticosum fruit (seed) reflected into an array of pharmacological assays and prospective receptors-mediated pathways
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921944/
https://www.ncbi.nlm.nih.gov/pubmed/33671381
http://dx.doi.org/10.3390/life11020155
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