Increased Regulatory T Cells and Decreased Myeloid-Derived Suppressor Cells Induced by High CCL17 Levels May Account for Normal Incidence of Cancers among Patients with Atopic Dermatitis

The incidence of cancers in atopic dermatitis (AD) is not increased, although the Th2-dominant environment is known to downregulate tumor immunity. To gain mechanistic insights regarding tumor immunity in AD, we utilized CCL17 transgenic (TG) mice overexpressing CCL17, which is a key chemokine in AD...

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Detalles Bibliográficos
Autores principales: Morimura, Sohshi, Sugaya, Makoto, Oka, Tomonori, Suga, Hiraku, Miyagaki, Tomomitsu, Tsunemi, Yuichiro, Asano, Yoshihide, Sato, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922104/
https://www.ncbi.nlm.nih.gov/pubmed/33670758
http://dx.doi.org/10.3390/ijms22042025

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