Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from Aerides multiflora and Their α-Glucosidase Inhibitory Activity

A phytochemical investigation on the whole plants of Aerides multiflora revealed the presence of three new biphenanthrene derivatives named aerimultins A–C (1–3) and a new natural phenylpropanoid ester dihydrosinapyl dihydroferulate (4), together with six known compounds (5–10). The structures of th...

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Autores principales: Thant, May Thazin, Sritularak, Boonchoo, Chatsumpun, Nutputsorn, Mekboonsonglarp, Wanwimon, Punpreuk, Yanyong, Likhitwitayawuid, Kittisak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922108/
https://www.ncbi.nlm.nih.gov/pubmed/33671404
http://dx.doi.org/10.3390/plants10020385
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author Thant, May Thazin
Sritularak, Boonchoo
Chatsumpun, Nutputsorn
Mekboonsonglarp, Wanwimon
Punpreuk, Yanyong
Likhitwitayawuid, Kittisak
author_facet Thant, May Thazin
Sritularak, Boonchoo
Chatsumpun, Nutputsorn
Mekboonsonglarp, Wanwimon
Punpreuk, Yanyong
Likhitwitayawuid, Kittisak
author_sort Thant, May Thazin
collection PubMed
description A phytochemical investigation on the whole plants of Aerides multiflora revealed the presence of three new biphenanthrene derivatives named aerimultins A–C (1–3) and a new natural phenylpropanoid ester dihydrosinapyl dihydroferulate (4), together with six known compounds (5–10). The structures of the new compounds were elucidated by analysis of their spectroscopic data. All of the isolates were evaluated for their α-glucosidase inhibitory activity. Aerimultin C (3) showed the most potent activity. The other compounds, except for compound 4, also exhibited stronger activity than the positive control acarbose. Compound 3 showed non-competitive inhibition of the enzyme as determined from a Lineweaver–Burk plot. This study is the first phytochemical and biological investigation of A. multiflora.
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spelling pubmed-79221082021-03-03 Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from Aerides multiflora and Their α-Glucosidase Inhibitory Activity Thant, May Thazin Sritularak, Boonchoo Chatsumpun, Nutputsorn Mekboonsonglarp, Wanwimon Punpreuk, Yanyong Likhitwitayawuid, Kittisak Plants (Basel) Article A phytochemical investigation on the whole plants of Aerides multiflora revealed the presence of three new biphenanthrene derivatives named aerimultins A–C (1–3) and a new natural phenylpropanoid ester dihydrosinapyl dihydroferulate (4), together with six known compounds (5–10). The structures of the new compounds were elucidated by analysis of their spectroscopic data. All of the isolates were evaluated for their α-glucosidase inhibitory activity. Aerimultin C (3) showed the most potent activity. The other compounds, except for compound 4, also exhibited stronger activity than the positive control acarbose. Compound 3 showed non-competitive inhibition of the enzyme as determined from a Lineweaver–Burk plot. This study is the first phytochemical and biological investigation of A. multiflora. MDPI 2021-02-17 /pmc/articles/PMC7922108/ /pubmed/33671404 http://dx.doi.org/10.3390/plants10020385 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thant, May Thazin
Sritularak, Boonchoo
Chatsumpun, Nutputsorn
Mekboonsonglarp, Wanwimon
Punpreuk, Yanyong
Likhitwitayawuid, Kittisak
Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from Aerides multiflora and Their α-Glucosidase Inhibitory Activity
title Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from Aerides multiflora and Their α-Glucosidase Inhibitory Activity
title_full Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from Aerides multiflora and Their α-Glucosidase Inhibitory Activity
title_fullStr Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from Aerides multiflora and Their α-Glucosidase Inhibitory Activity
title_full_unstemmed Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from Aerides multiflora and Their α-Glucosidase Inhibitory Activity
title_short Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from Aerides multiflora and Their α-Glucosidase Inhibitory Activity
title_sort three novel biphenanthrene derivatives and a new phenylpropanoid ester from aerides multiflora and their α-glucosidase inhibitory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922108/
https://www.ncbi.nlm.nih.gov/pubmed/33671404
http://dx.doi.org/10.3390/plants10020385
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