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Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances

In the present era, infertility is one of the major issues which restricts many couples to have their own children. Infertility is the inability to achieve a clinical pregnancy after regular unprotected sexual intercourse for the period of one year or more. Various factors including defective male o...

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Autores principales: Bharti, Dinesh, Tikka, Manisha, Lee, Sang-Yun, Bok, Eun-Yeong, Lee, Hyeon-Jeong, Rho, Gyu-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922109/
https://www.ncbi.nlm.nih.gov/pubmed/33671303
http://dx.doi.org/10.3390/ijms22041979
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author Bharti, Dinesh
Tikka, Manisha
Lee, Sang-Yun
Bok, Eun-Yeong
Lee, Hyeon-Jeong
Rho, Gyu-Jin
author_facet Bharti, Dinesh
Tikka, Manisha
Lee, Sang-Yun
Bok, Eun-Yeong
Lee, Hyeon-Jeong
Rho, Gyu-Jin
author_sort Bharti, Dinesh
collection PubMed
description In the present era, infertility is one of the major issues which restricts many couples to have their own children. Infertility is the inability to achieve a clinical pregnancy after regular unprotected sexual intercourse for the period of one year or more. Various factors including defective male or female germ cell development, unhealthy and improper lifestyles, diseases like cancer and associated chemo-or-radiation therapies, congenital disorders, etc., may be responsible for infertility. Therefore, it is highly important to understand the basic concepts of germ cell development including primordial germ cell (PGC) formation, specification, migration, entry to genital ridges and their molecular mechanisms, activated pathways, paracrine and autocrine signaling, along with possible alteration which can hamper germ cell development and can cause adversities like cancer progression and infertility. Knowing all these aspects in a proper way can be very much helpful in improving our understanding about gametogenesis and finding possible ways to cure related disorders. Here in this review, various aspects of gametogenesis especially female gametes and relevant factors causing functional impairment have been thoroughly discussed.
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spelling pubmed-79221092021-03-03 Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances Bharti, Dinesh Tikka, Manisha Lee, Sang-Yun Bok, Eun-Yeong Lee, Hyeon-Jeong Rho, Gyu-Jin Int J Mol Sci Review In the present era, infertility is one of the major issues which restricts many couples to have their own children. Infertility is the inability to achieve a clinical pregnancy after regular unprotected sexual intercourse for the period of one year or more. Various factors including defective male or female germ cell development, unhealthy and improper lifestyles, diseases like cancer and associated chemo-or-radiation therapies, congenital disorders, etc., may be responsible for infertility. Therefore, it is highly important to understand the basic concepts of germ cell development including primordial germ cell (PGC) formation, specification, migration, entry to genital ridges and their molecular mechanisms, activated pathways, paracrine and autocrine signaling, along with possible alteration which can hamper germ cell development and can cause adversities like cancer progression and infertility. Knowing all these aspects in a proper way can be very much helpful in improving our understanding about gametogenesis and finding possible ways to cure related disorders. Here in this review, various aspects of gametogenesis especially female gametes and relevant factors causing functional impairment have been thoroughly discussed. MDPI 2021-02-17 /pmc/articles/PMC7922109/ /pubmed/33671303 http://dx.doi.org/10.3390/ijms22041979 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bharti, Dinesh
Tikka, Manisha
Lee, Sang-Yun
Bok, Eun-Yeong
Lee, Hyeon-Jeong
Rho, Gyu-Jin
Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances
title Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances
title_full Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances
title_fullStr Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances
title_full_unstemmed Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances
title_short Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances
title_sort female germ cell development, functioning and associated adversities under unfavorable circumstances
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922109/
https://www.ncbi.nlm.nih.gov/pubmed/33671303
http://dx.doi.org/10.3390/ijms22041979
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