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Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer

The underlying molecular heterogeneity of cancer is responsible for the dynamic clinical landscape of this disease. The combination of genomic and proteomic alterations, including both inherited and acquired mutations, promotes tumor diversity and accounts for variable disease progression, therapeut...

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Detalles Bibliográficos
Autores principales: Khella, Christen A., Mehta, Gaurav A., Mehta, Rushabh N., Gatza, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922242/
https://www.ncbi.nlm.nih.gov/pubmed/33669749
http://dx.doi.org/10.3390/jpm11020149
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author Khella, Christen A.
Mehta, Gaurav A.
Mehta, Rushabh N.
Gatza, Michael L.
author_facet Khella, Christen A.
Mehta, Gaurav A.
Mehta, Rushabh N.
Gatza, Michael L.
author_sort Khella, Christen A.
collection PubMed
description The underlying molecular heterogeneity of cancer is responsible for the dynamic clinical landscape of this disease. The combination of genomic and proteomic alterations, including both inherited and acquired mutations, promotes tumor diversity and accounts for variable disease progression, therapeutic response, and clinical outcome. Recent advances in high-throughput proteogenomic profiling of tumor samples have resulted in the identification of novel oncogenic drivers, tumor suppressors, and signaling networks; biomarkers for the prediction of drug sensitivity and disease progression; and have contributed to the development of novel and more effective treatment strategies. In this review, we will focus on the impact of historical and recent advances in single platform and integrative proteogenomic studies in breast and ovarian cancer, which constitute two of the most lethal forms of cancer for women, and discuss the molecular similarities of these diseases, the impact of these findings on our understanding of tumor biology as well as the clinical applicability of these discoveries.
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spelling pubmed-79222422021-03-03 Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer Khella, Christen A. Mehta, Gaurav A. Mehta, Rushabh N. Gatza, Michael L. J Pers Med Review The underlying molecular heterogeneity of cancer is responsible for the dynamic clinical landscape of this disease. The combination of genomic and proteomic alterations, including both inherited and acquired mutations, promotes tumor diversity and accounts for variable disease progression, therapeutic response, and clinical outcome. Recent advances in high-throughput proteogenomic profiling of tumor samples have resulted in the identification of novel oncogenic drivers, tumor suppressors, and signaling networks; biomarkers for the prediction of drug sensitivity and disease progression; and have contributed to the development of novel and more effective treatment strategies. In this review, we will focus on the impact of historical and recent advances in single platform and integrative proteogenomic studies in breast and ovarian cancer, which constitute two of the most lethal forms of cancer for women, and discuss the molecular similarities of these diseases, the impact of these findings on our understanding of tumor biology as well as the clinical applicability of these discoveries. MDPI 2021-02-19 /pmc/articles/PMC7922242/ /pubmed/33669749 http://dx.doi.org/10.3390/jpm11020149 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khella, Christen A.
Mehta, Gaurav A.
Mehta, Rushabh N.
Gatza, Michael L.
Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer
title Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer
title_full Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer
title_fullStr Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer
title_full_unstemmed Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer
title_short Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer
title_sort recent advances in integrative multi-omics research in breast and ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922242/
https://www.ncbi.nlm.nih.gov/pubmed/33669749
http://dx.doi.org/10.3390/jpm11020149
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