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Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer
The underlying molecular heterogeneity of cancer is responsible for the dynamic clinical landscape of this disease. The combination of genomic and proteomic alterations, including both inherited and acquired mutations, promotes tumor diversity and accounts for variable disease progression, therapeut...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922242/ https://www.ncbi.nlm.nih.gov/pubmed/33669749 http://dx.doi.org/10.3390/jpm11020149 |
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author | Khella, Christen A. Mehta, Gaurav A. Mehta, Rushabh N. Gatza, Michael L. |
author_facet | Khella, Christen A. Mehta, Gaurav A. Mehta, Rushabh N. Gatza, Michael L. |
author_sort | Khella, Christen A. |
collection | PubMed |
description | The underlying molecular heterogeneity of cancer is responsible for the dynamic clinical landscape of this disease. The combination of genomic and proteomic alterations, including both inherited and acquired mutations, promotes tumor diversity and accounts for variable disease progression, therapeutic response, and clinical outcome. Recent advances in high-throughput proteogenomic profiling of tumor samples have resulted in the identification of novel oncogenic drivers, tumor suppressors, and signaling networks; biomarkers for the prediction of drug sensitivity and disease progression; and have contributed to the development of novel and more effective treatment strategies. In this review, we will focus on the impact of historical and recent advances in single platform and integrative proteogenomic studies in breast and ovarian cancer, which constitute two of the most lethal forms of cancer for women, and discuss the molecular similarities of these diseases, the impact of these findings on our understanding of tumor biology as well as the clinical applicability of these discoveries. |
format | Online Article Text |
id | pubmed-7922242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79222422021-03-03 Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer Khella, Christen A. Mehta, Gaurav A. Mehta, Rushabh N. Gatza, Michael L. J Pers Med Review The underlying molecular heterogeneity of cancer is responsible for the dynamic clinical landscape of this disease. The combination of genomic and proteomic alterations, including both inherited and acquired mutations, promotes tumor diversity and accounts for variable disease progression, therapeutic response, and clinical outcome. Recent advances in high-throughput proteogenomic profiling of tumor samples have resulted in the identification of novel oncogenic drivers, tumor suppressors, and signaling networks; biomarkers for the prediction of drug sensitivity and disease progression; and have contributed to the development of novel and more effective treatment strategies. In this review, we will focus on the impact of historical and recent advances in single platform and integrative proteogenomic studies in breast and ovarian cancer, which constitute two of the most lethal forms of cancer for women, and discuss the molecular similarities of these diseases, the impact of these findings on our understanding of tumor biology as well as the clinical applicability of these discoveries. MDPI 2021-02-19 /pmc/articles/PMC7922242/ /pubmed/33669749 http://dx.doi.org/10.3390/jpm11020149 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Khella, Christen A. Mehta, Gaurav A. Mehta, Rushabh N. Gatza, Michael L. Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer |
title | Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer |
title_full | Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer |
title_fullStr | Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer |
title_full_unstemmed | Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer |
title_short | Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer |
title_sort | recent advances in integrative multi-omics research in breast and ovarian cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922242/ https://www.ncbi.nlm.nih.gov/pubmed/33669749 http://dx.doi.org/10.3390/jpm11020149 |
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