Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433

The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical structures of these compounds were...

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Autores principales: Khan, Imran, Peng, Jing, Fang, Zhuangjie, Liu, Wei, Zhang, Wenjun, Zhang, Qingbo, Ma, Liang, Zhang, Guangtao, Zhang, Changsheng, Zhang, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922244/
https://www.ncbi.nlm.nih.gov/pubmed/33670784
http://dx.doi.org/10.3390/molecules26041080
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author Khan, Imran
Peng, Jing
Fang, Zhuangjie
Liu, Wei
Zhang, Wenjun
Zhang, Qingbo
Ma, Liang
Zhang, Guangtao
Zhang, Changsheng
Zhang, Haibo
author_facet Khan, Imran
Peng, Jing
Fang, Zhuangjie
Liu, Wei
Zhang, Wenjun
Zhang, Qingbo
Ma, Liang
Zhang, Guangtao
Zhang, Changsheng
Zhang, Haibo
author_sort Khan, Imran
collection PubMed
description The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin (1) featured a 3,4-dihydro-2H-pyran skeleton. The absolute configuration of compound 1 was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin (1) exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products.
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spelling pubmed-79222442021-03-03 Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433 Khan, Imran Peng, Jing Fang, Zhuangjie Liu, Wei Zhang, Wenjun Zhang, Qingbo Ma, Liang Zhang, Guangtao Zhang, Changsheng Zhang, Haibo Molecules Article The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin (1) featured a 3,4-dihydro-2H-pyran skeleton. The absolute configuration of compound 1 was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin (1) exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products. MDPI 2021-02-18 /pmc/articles/PMC7922244/ /pubmed/33670784 http://dx.doi.org/10.3390/molecules26041080 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khan, Imran
Peng, Jing
Fang, Zhuangjie
Liu, Wei
Zhang, Wenjun
Zhang, Qingbo
Ma, Liang
Zhang, Guangtao
Zhang, Changsheng
Zhang, Haibo
Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433
title Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433
title_full Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433
title_fullStr Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433
title_full_unstemmed Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433
title_short Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433
title_sort cylindromicin from arctic-derived fungus tolypocladium sp. scsio 40433
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922244/
https://www.ncbi.nlm.nih.gov/pubmed/33670784
http://dx.doi.org/10.3390/molecules26041080
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