Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model

SIMPLE SUMMARY: Chimeric antigen receptors (CARs) redirect T cells without the need for major histocompatibility complex (MHC) restriction. CARs are designed based on T cell receptor (TCR) signaling and the recognition specificities of antibodies. This technology has achieved great clinical success...

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Detalles Bibliográficos
Autores principales: Wu, Ling, Brzostek, Joanna, Sankaran, Shvetha, Wei, Qianru, Yap, Jiawei, Tan, Triscilla Y.Y., Lai, Junyun, MacAry, Paul A., Gascoigne, Nicholas R. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922477/
https://www.ncbi.nlm.nih.gov/pubmed/33670734
http://dx.doi.org/10.3390/cancers13040867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922477/
https://www.ncbi.nlm.nih.gov/pubmed/33670734
http://dx.doi.org/10.3390/cancers13040867

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