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Limited Sampling Strategy for Determination of Ibrutinib Plasma Exposure: Joint Analyses with Metabolite Data
Therapeutic drug monitoring of ibrutinib is based on the area under the curve of concentration vs. time (AUC(IBRU)) instead of trough concentration (C(min,ss)) because of a limited accumulation in plasma. Our objective was to identify a limited sampling strategy (LSS) to estimate AUC(IBRU) associate...
Autores principales: | Le Louedec, Félicien, Gallais, Fanny, Thomas, Fabienne, White-Koning, Mélanie, Allal, Ben, Protin, Caroline, Ysebaert, Loïc, Chatelut, Étienne, Puisset, Florent |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922501/ https://www.ncbi.nlm.nih.gov/pubmed/33670575 http://dx.doi.org/10.3390/ph14020162 |
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