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Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder
(1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922535/ https://www.ncbi.nlm.nih.gov/pubmed/33671238 http://dx.doi.org/10.3390/healthcare9020217 |
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author | Luan, Chih-Wei Chen, Chih-Cheng Lee, Kam-Fai Tsai, Ming-Shao Tsai, Yao-Te Hsu, Cheng-Ming Chang, Geng-He |
author_facet | Luan, Chih-Wei Chen, Chih-Cheng Lee, Kam-Fai Tsai, Ming-Shao Tsai, Yao-Te Hsu, Cheng-Ming Chang, Geng-He |
author_sort | Luan, Chih-Wei |
collection | PubMed |
description | (1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of PTLD after bone marrow transplantation, are uncommon. (2) Case presentation: We report the case of a 40-year-old woman with myelodysplastic disorder who underwent hematopoietic stem cell transplantation (HSCT). After 3 months, she developed low-grade fever, progressive nasal obstruction, and bloody rhinorrhea. Endoscopy revealed a mass completely occupying the nasopharynx. A polymorphic PTLD was diagnosed on the basis of histopathological examination results. Reduction in immunosuppression and low-dose radiotherapy were prescribed for treatment. After a 3-year follow-up, no recurrence of PTLD or myelodysplastic disorder was detected. (3) Conclusions: While nasopharyngeal PTLD is rare, a routine examination of the nasopharynx should be considered in the post-transplant follow-up of patients for early detection and treatment of PTLD. |
format | Online Article Text |
id | pubmed-7922535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79225352021-03-03 Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder Luan, Chih-Wei Chen, Chih-Cheng Lee, Kam-Fai Tsai, Ming-Shao Tsai, Yao-Te Hsu, Cheng-Ming Chang, Geng-He Healthcare (Basel) Case Report (1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of PTLD after bone marrow transplantation, are uncommon. (2) Case presentation: We report the case of a 40-year-old woman with myelodysplastic disorder who underwent hematopoietic stem cell transplantation (HSCT). After 3 months, she developed low-grade fever, progressive nasal obstruction, and bloody rhinorrhea. Endoscopy revealed a mass completely occupying the nasopharynx. A polymorphic PTLD was diagnosed on the basis of histopathological examination results. Reduction in immunosuppression and low-dose radiotherapy were prescribed for treatment. After a 3-year follow-up, no recurrence of PTLD or myelodysplastic disorder was detected. (3) Conclusions: While nasopharyngeal PTLD is rare, a routine examination of the nasopharynx should be considered in the post-transplant follow-up of patients for early detection and treatment of PTLD. MDPI 2021-02-17 /pmc/articles/PMC7922535/ /pubmed/33671238 http://dx.doi.org/10.3390/healthcare9020217 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Luan, Chih-Wei Chen, Chih-Cheng Lee, Kam-Fai Tsai, Ming-Shao Tsai, Yao-Te Hsu, Cheng-Ming Chang, Geng-He Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder |
title | Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder |
title_full | Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder |
title_fullStr | Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder |
title_full_unstemmed | Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder |
title_short | Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder |
title_sort | malignant post-transplant lymphoproliferative disorder of nasopharynx in myelodysplastic disorder |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922535/ https://www.ncbi.nlm.nih.gov/pubmed/33671238 http://dx.doi.org/10.3390/healthcare9020217 |
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