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Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder

(1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of...

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Autores principales: Luan, Chih-Wei, Chen, Chih-Cheng, Lee, Kam-Fai, Tsai, Ming-Shao, Tsai, Yao-Te, Hsu, Cheng-Ming, Chang, Geng-He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922535/
https://www.ncbi.nlm.nih.gov/pubmed/33671238
http://dx.doi.org/10.3390/healthcare9020217
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author Luan, Chih-Wei
Chen, Chih-Cheng
Lee, Kam-Fai
Tsai, Ming-Shao
Tsai, Yao-Te
Hsu, Cheng-Ming
Chang, Geng-He
author_facet Luan, Chih-Wei
Chen, Chih-Cheng
Lee, Kam-Fai
Tsai, Ming-Shao
Tsai, Yao-Te
Hsu, Cheng-Ming
Chang, Geng-He
author_sort Luan, Chih-Wei
collection PubMed
description (1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of PTLD after bone marrow transplantation, are uncommon. (2) Case presentation: We report the case of a 40-year-old woman with myelodysplastic disorder who underwent hematopoietic stem cell transplantation (HSCT). After 3 months, she developed low-grade fever, progressive nasal obstruction, and bloody rhinorrhea. Endoscopy revealed a mass completely occupying the nasopharynx. A polymorphic PTLD was diagnosed on the basis of histopathological examination results. Reduction in immunosuppression and low-dose radiotherapy were prescribed for treatment. After a 3-year follow-up, no recurrence of PTLD or myelodysplastic disorder was detected. (3) Conclusions: While nasopharyngeal PTLD is rare, a routine examination of the nasopharynx should be considered in the post-transplant follow-up of patients for early detection and treatment of PTLD.
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spelling pubmed-79225352021-03-03 Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder Luan, Chih-Wei Chen, Chih-Cheng Lee, Kam-Fai Tsai, Ming-Shao Tsai, Yao-Te Hsu, Cheng-Ming Chang, Geng-He Healthcare (Basel) Case Report (1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of PTLD after bone marrow transplantation, are uncommon. (2) Case presentation: We report the case of a 40-year-old woman with myelodysplastic disorder who underwent hematopoietic stem cell transplantation (HSCT). After 3 months, she developed low-grade fever, progressive nasal obstruction, and bloody rhinorrhea. Endoscopy revealed a mass completely occupying the nasopharynx. A polymorphic PTLD was diagnosed on the basis of histopathological examination results. Reduction in immunosuppression and low-dose radiotherapy were prescribed for treatment. After a 3-year follow-up, no recurrence of PTLD or myelodysplastic disorder was detected. (3) Conclusions: While nasopharyngeal PTLD is rare, a routine examination of the nasopharynx should be considered in the post-transplant follow-up of patients for early detection and treatment of PTLD. MDPI 2021-02-17 /pmc/articles/PMC7922535/ /pubmed/33671238 http://dx.doi.org/10.3390/healthcare9020217 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Luan, Chih-Wei
Chen, Chih-Cheng
Lee, Kam-Fai
Tsai, Ming-Shao
Tsai, Yao-Te
Hsu, Cheng-Ming
Chang, Geng-He
Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder
title Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder
title_full Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder
title_fullStr Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder
title_full_unstemmed Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder
title_short Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder
title_sort malignant post-transplant lymphoproliferative disorder of nasopharynx in myelodysplastic disorder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922535/
https://www.ncbi.nlm.nih.gov/pubmed/33671238
http://dx.doi.org/10.3390/healthcare9020217
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