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Association of Sepsis Mortality with Specific Cancer Sites and Treatment Type: The Multiethnic Cohort Study

Sepsis is a severe dysregulated immune response to infection. Sepsis deaths represent 9% of cancer deaths in the U.S. Evidence of the effect of specific cancer sites on sepsis mortality risk remains limited, and no research has evaluated the effect of cancer treatment on the risk of sepsis death. We...

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Autores principales: Shvetsov, Yurii B., Ogino, Mari H., Glibetic, Natalija, Asato, Chloe B., Wilkens, Lynne R., Le Marchand, Loïc, Matter, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922684/
https://www.ncbi.nlm.nih.gov/pubmed/33669565
http://dx.doi.org/10.3390/jpm11020146
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author Shvetsov, Yurii B.
Ogino, Mari H.
Glibetic, Natalija
Asato, Chloe B.
Wilkens, Lynne R.
Le Marchand, Loïc
Matter, Michelle L.
author_facet Shvetsov, Yurii B.
Ogino, Mari H.
Glibetic, Natalija
Asato, Chloe B.
Wilkens, Lynne R.
Le Marchand, Loïc
Matter, Michelle L.
author_sort Shvetsov, Yurii B.
collection PubMed
description Sepsis is a severe dysregulated immune response to infection. Sepsis deaths represent 9% of cancer deaths in the U.S. Evidence of the effect of specific cancer sites on sepsis mortality risk remains limited, and no research has evaluated the effect of cancer treatment on the risk of sepsis death. We examined whether cancer sites and treatments differentially affect the risk of sepsis death compared to other-cause mortality, among the 94,784 Hawaii participants in the Multiethnic Cohort, including 29,255 cancer cases, using competing risk Cox proportional hazards regression. Cancer diagnosis at any site was associated with similar increases in sepsis and non-sepsis mortality risk (HR: 3.39 and 3.51, resp.). Colorectal cancer differentially affected the risk of sepsis and non-sepsis mortality with a 40% higher effect on the risk of sepsis death compared with non-sepsis mortality (RRR: 1.40; 95% CI: 1.14–1.72). Lung cancer was associated with a significantly lower increase in sepsis compared to non-sepsis mortality (HR: 1.22 and 3.0, resp.; RRR: 0.39). Radiation therapy had no effect on sepsis mortality but was associated with higher risk of non-sepsis mortality (HR: 0.90 and 1.16, resp.; RRR: 0.76), whereas chemotherapy was associated with higher risk of both sepsis and non-sepsis mortality (HR: 1.31 and 1.21, resp.). We conclude that the risk of sepsis-related mortality is differentially affected by cancer sites and treatments. These associations were consistent across sexes and ethnic groups.
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spelling pubmed-79226842021-03-03 Association of Sepsis Mortality with Specific Cancer Sites and Treatment Type: The Multiethnic Cohort Study Shvetsov, Yurii B. Ogino, Mari H. Glibetic, Natalija Asato, Chloe B. Wilkens, Lynne R. Le Marchand, Loïc Matter, Michelle L. J Pers Med Article Sepsis is a severe dysregulated immune response to infection. Sepsis deaths represent 9% of cancer deaths in the U.S. Evidence of the effect of specific cancer sites on sepsis mortality risk remains limited, and no research has evaluated the effect of cancer treatment on the risk of sepsis death. We examined whether cancer sites and treatments differentially affect the risk of sepsis death compared to other-cause mortality, among the 94,784 Hawaii participants in the Multiethnic Cohort, including 29,255 cancer cases, using competing risk Cox proportional hazards regression. Cancer diagnosis at any site was associated with similar increases in sepsis and non-sepsis mortality risk (HR: 3.39 and 3.51, resp.). Colorectal cancer differentially affected the risk of sepsis and non-sepsis mortality with a 40% higher effect on the risk of sepsis death compared with non-sepsis mortality (RRR: 1.40; 95% CI: 1.14–1.72). Lung cancer was associated with a significantly lower increase in sepsis compared to non-sepsis mortality (HR: 1.22 and 3.0, resp.; RRR: 0.39). Radiation therapy had no effect on sepsis mortality but was associated with higher risk of non-sepsis mortality (HR: 0.90 and 1.16, resp.; RRR: 0.76), whereas chemotherapy was associated with higher risk of both sepsis and non-sepsis mortality (HR: 1.31 and 1.21, resp.). We conclude that the risk of sepsis-related mortality is differentially affected by cancer sites and treatments. These associations were consistent across sexes and ethnic groups. MDPI 2021-02-19 /pmc/articles/PMC7922684/ /pubmed/33669565 http://dx.doi.org/10.3390/jpm11020146 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shvetsov, Yurii B.
Ogino, Mari H.
Glibetic, Natalija
Asato, Chloe B.
Wilkens, Lynne R.
Le Marchand, Loïc
Matter, Michelle L.
Association of Sepsis Mortality with Specific Cancer Sites and Treatment Type: The Multiethnic Cohort Study
title Association of Sepsis Mortality with Specific Cancer Sites and Treatment Type: The Multiethnic Cohort Study
title_full Association of Sepsis Mortality with Specific Cancer Sites and Treatment Type: The Multiethnic Cohort Study
title_fullStr Association of Sepsis Mortality with Specific Cancer Sites and Treatment Type: The Multiethnic Cohort Study
title_full_unstemmed Association of Sepsis Mortality with Specific Cancer Sites and Treatment Type: The Multiethnic Cohort Study
title_short Association of Sepsis Mortality with Specific Cancer Sites and Treatment Type: The Multiethnic Cohort Study
title_sort association of sepsis mortality with specific cancer sites and treatment type: the multiethnic cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922684/
https://www.ncbi.nlm.nih.gov/pubmed/33669565
http://dx.doi.org/10.3390/jpm11020146
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