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Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis

Plasma cell gingivitis (PCG) is an infrequent inflammatory disease of the gingiva of unknown etiology, characterized by a dense polyclonal proliferation of plasma cells in the connective tissue. The aim of this study was to present a case series of patients affected by PCG, analyzing demographic, cl...

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Autores principales: Leuci, Stefania, Coppola, Noemi, Adamo, Nicola, Bizzoca, Maria Eleonora, Russo, Daniela, Spagnuolo, Gianrico, Lo Muzio, Lorenzo, Mignogna, Michele Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922699/
https://www.ncbi.nlm.nih.gov/pubmed/33670562
http://dx.doi.org/10.3390/jcm10040830
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author Leuci, Stefania
Coppola, Noemi
Adamo, Nicola
Bizzoca, Maria Eleonora
Russo, Daniela
Spagnuolo, Gianrico
Lo Muzio, Lorenzo
Mignogna, Michele Davide
author_facet Leuci, Stefania
Coppola, Noemi
Adamo, Nicola
Bizzoca, Maria Eleonora
Russo, Daniela
Spagnuolo, Gianrico
Lo Muzio, Lorenzo
Mignogna, Michele Davide
author_sort Leuci, Stefania
collection PubMed
description Plasma cell gingivitis (PCG) is an infrequent inflammatory disease of the gingiva of unknown etiology, characterized by a dense polyclonal proliferation of plasma cells in the connective tissue. The aim of this study was to present a case series of patients affected by PCG, analyzing demographic, clinical, histopathological, and therapeutic data. A group of 36 females and 9 males with a mean age of 60.3 years was evaluated. Clinically, 25 cases were bullous, a clinical phenotype never reported to date, 4 erythematous, 4 keratotic, 4 verruciform, and 3 ulcerative. On histological examination, pure polyclonal plasma cell infiltrate was detected in 20 specimens, while in 25 specimens it was associated with a mixed infiltrate. The first-line therapy consisted of oral hygiene and topical corticosteroids in all patients. In 25 patients, doxycycline and sulfasalazine were added; in 10 of these patients, the disease persisted, and it was necessary to resort to systemic steroids. This study presented the clinico-pathological profile and outcomes of a case series of PCG. This could be an aid for clinicians to be aware of the heterogeneous clinical phenotype and of the possible pure bullous phenotype of PCG. Further studies are needed to improve the knowledge about this disorder.
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spelling pubmed-79226992021-03-03 Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis Leuci, Stefania Coppola, Noemi Adamo, Nicola Bizzoca, Maria Eleonora Russo, Daniela Spagnuolo, Gianrico Lo Muzio, Lorenzo Mignogna, Michele Davide J Clin Med Article Plasma cell gingivitis (PCG) is an infrequent inflammatory disease of the gingiva of unknown etiology, characterized by a dense polyclonal proliferation of plasma cells in the connective tissue. The aim of this study was to present a case series of patients affected by PCG, analyzing demographic, clinical, histopathological, and therapeutic data. A group of 36 females and 9 males with a mean age of 60.3 years was evaluated. Clinically, 25 cases were bullous, a clinical phenotype never reported to date, 4 erythematous, 4 keratotic, 4 verruciform, and 3 ulcerative. On histological examination, pure polyclonal plasma cell infiltrate was detected in 20 specimens, while in 25 specimens it was associated with a mixed infiltrate. The first-line therapy consisted of oral hygiene and topical corticosteroids in all patients. In 25 patients, doxycycline and sulfasalazine were added; in 10 of these patients, the disease persisted, and it was necessary to resort to systemic steroids. This study presented the clinico-pathological profile and outcomes of a case series of PCG. This could be an aid for clinicians to be aware of the heterogeneous clinical phenotype and of the possible pure bullous phenotype of PCG. Further studies are needed to improve the knowledge about this disorder. MDPI 2021-02-18 /pmc/articles/PMC7922699/ /pubmed/33670562 http://dx.doi.org/10.3390/jcm10040830 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leuci, Stefania
Coppola, Noemi
Adamo, Nicola
Bizzoca, Maria Eleonora
Russo, Daniela
Spagnuolo, Gianrico
Lo Muzio, Lorenzo
Mignogna, Michele Davide
Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis
title Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis
title_full Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis
title_fullStr Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis
title_full_unstemmed Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis
title_short Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis
title_sort clinico-pathological profile and outcomes of 45 cases of plasma cell gingivitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922699/
https://www.ncbi.nlm.nih.gov/pubmed/33670562
http://dx.doi.org/10.3390/jcm10040830
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