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Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis
Plasma cell gingivitis (PCG) is an infrequent inflammatory disease of the gingiva of unknown etiology, characterized by a dense polyclonal proliferation of plasma cells in the connective tissue. The aim of this study was to present a case series of patients affected by PCG, analyzing demographic, cl...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922699/ https://www.ncbi.nlm.nih.gov/pubmed/33670562 http://dx.doi.org/10.3390/jcm10040830 |
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author | Leuci, Stefania Coppola, Noemi Adamo, Nicola Bizzoca, Maria Eleonora Russo, Daniela Spagnuolo, Gianrico Lo Muzio, Lorenzo Mignogna, Michele Davide |
author_facet | Leuci, Stefania Coppola, Noemi Adamo, Nicola Bizzoca, Maria Eleonora Russo, Daniela Spagnuolo, Gianrico Lo Muzio, Lorenzo Mignogna, Michele Davide |
author_sort | Leuci, Stefania |
collection | PubMed |
description | Plasma cell gingivitis (PCG) is an infrequent inflammatory disease of the gingiva of unknown etiology, characterized by a dense polyclonal proliferation of plasma cells in the connective tissue. The aim of this study was to present a case series of patients affected by PCG, analyzing demographic, clinical, histopathological, and therapeutic data. A group of 36 females and 9 males with a mean age of 60.3 years was evaluated. Clinically, 25 cases were bullous, a clinical phenotype never reported to date, 4 erythematous, 4 keratotic, 4 verruciform, and 3 ulcerative. On histological examination, pure polyclonal plasma cell infiltrate was detected in 20 specimens, while in 25 specimens it was associated with a mixed infiltrate. The first-line therapy consisted of oral hygiene and topical corticosteroids in all patients. In 25 patients, doxycycline and sulfasalazine were added; in 10 of these patients, the disease persisted, and it was necessary to resort to systemic steroids. This study presented the clinico-pathological profile and outcomes of a case series of PCG. This could be an aid for clinicians to be aware of the heterogeneous clinical phenotype and of the possible pure bullous phenotype of PCG. Further studies are needed to improve the knowledge about this disorder. |
format | Online Article Text |
id | pubmed-7922699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79226992021-03-03 Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis Leuci, Stefania Coppola, Noemi Adamo, Nicola Bizzoca, Maria Eleonora Russo, Daniela Spagnuolo, Gianrico Lo Muzio, Lorenzo Mignogna, Michele Davide J Clin Med Article Plasma cell gingivitis (PCG) is an infrequent inflammatory disease of the gingiva of unknown etiology, characterized by a dense polyclonal proliferation of plasma cells in the connective tissue. The aim of this study was to present a case series of patients affected by PCG, analyzing demographic, clinical, histopathological, and therapeutic data. A group of 36 females and 9 males with a mean age of 60.3 years was evaluated. Clinically, 25 cases were bullous, a clinical phenotype never reported to date, 4 erythematous, 4 keratotic, 4 verruciform, and 3 ulcerative. On histological examination, pure polyclonal plasma cell infiltrate was detected in 20 specimens, while in 25 specimens it was associated with a mixed infiltrate. The first-line therapy consisted of oral hygiene and topical corticosteroids in all patients. In 25 patients, doxycycline and sulfasalazine were added; in 10 of these patients, the disease persisted, and it was necessary to resort to systemic steroids. This study presented the clinico-pathological profile and outcomes of a case series of PCG. This could be an aid for clinicians to be aware of the heterogeneous clinical phenotype and of the possible pure bullous phenotype of PCG. Further studies are needed to improve the knowledge about this disorder. MDPI 2021-02-18 /pmc/articles/PMC7922699/ /pubmed/33670562 http://dx.doi.org/10.3390/jcm10040830 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Leuci, Stefania Coppola, Noemi Adamo, Nicola Bizzoca, Maria Eleonora Russo, Daniela Spagnuolo, Gianrico Lo Muzio, Lorenzo Mignogna, Michele Davide Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
title | Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
title_full | Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
title_fullStr | Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
title_full_unstemmed | Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
title_short | Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
title_sort | clinico-pathological profile and outcomes of 45 cases of plasma cell gingivitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922699/ https://www.ncbi.nlm.nih.gov/pubmed/33670562 http://dx.doi.org/10.3390/jcm10040830 |
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