Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe

Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2–5). Structure elucidation was conducted by nuclear magnetic resonance (NM...

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Autores principales: Cadelis, Melissa M., Geese, Soeren, Uy, Benedict B., Mulholland, Daniel R., van de Pas, Shara J., Grey, Alex, Weir, Bevan S., Copp, Brent R., Wiles, Siouxsie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922810/
https://www.ncbi.nlm.nih.gov/pubmed/33669637
http://dx.doi.org/10.3390/molecules26041094
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author Cadelis, Melissa M.
Geese, Soeren
Uy, Benedict B.
Mulholland, Daniel R.
van de Pas, Shara J.
Grey, Alex
Weir, Bevan S.
Copp, Brent R.
Wiles, Siouxsie
author_facet Cadelis, Melissa M.
Geese, Soeren
Uy, Benedict B.
Mulholland, Daniel R.
van de Pas, Shara J.
Grey, Alex
Weir, Bevan S.
Copp, Brent R.
Wiles, Siouxsie
author_sort Cadelis, Melissa M.
collection PubMed
description Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2–5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.
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spelling pubmed-79228102021-03-03 Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe Cadelis, Melissa M. Geese, Soeren Uy, Benedict B. Mulholland, Daniel R. van de Pas, Shara J. Grey, Alex Weir, Bevan S. Copp, Brent R. Wiles, Siouxsie Molecules Article Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2–5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL. MDPI 2021-02-19 /pmc/articles/PMC7922810/ /pubmed/33669637 http://dx.doi.org/10.3390/molecules26041094 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cadelis, Melissa M.
Geese, Soeren
Uy, Benedict B.
Mulholland, Daniel R.
van de Pas, Shara J.
Grey, Alex
Weir, Bevan S.
Copp, Brent R.
Wiles, Siouxsie
Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe
title Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe
title_full Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe
title_fullStr Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe
title_full_unstemmed Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe
title_short Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe
title_sort antimicrobial metabolites against methicillin-resistant staphylococcus aureus from the endophytic fungus neofusicoccum australe
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922810/
https://www.ncbi.nlm.nih.gov/pubmed/33669637
http://dx.doi.org/10.3390/molecules26041094
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