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Performance Characteristics of the Ultrasound Strategy during Incidence Screening in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

SIMPLE SUMMARY: The United Kingdom Collaborative Trial of Ovarian Cancer Screening was undertaken to assess whether screening postmenopausal women from the general population might result in detection of ovarian/tubal cancers at an earlier stage and thus save lives. One of the screening strategies t...

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Autores principales: Kalsi, Jatinderpal, Gentry-Maharaj, Aleksandra, Ryan, Andy, Singh, Naveena, Burnell, Matthew, Massingham, Susan, Apostolidou, Sophia, Sharma, Aarti, Williamson, Karin, Seif, Mourad, Mould, Tim, Woolas, Robert, Dobbs, Stephen, Leeson, Simon, Fallowfield, Lesley, Skates, Steven J., Parmar, Mahesh, Campbell, Stuart, Jacobs, Ian, McGuire, Alistair, Menon, Usha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922843/
https://www.ncbi.nlm.nih.gov/pubmed/33670571
http://dx.doi.org/10.3390/cancers13040858
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author Kalsi, Jatinderpal
Gentry-Maharaj, Aleksandra
Ryan, Andy
Singh, Naveena
Burnell, Matthew
Massingham, Susan
Apostolidou, Sophia
Sharma, Aarti
Williamson, Karin
Seif, Mourad
Mould, Tim
Woolas, Robert
Dobbs, Stephen
Leeson, Simon
Fallowfield, Lesley
Skates, Steven J.
Parmar, Mahesh
Campbell, Stuart
Jacobs, Ian
McGuire, Alistair
Menon, Usha
author_facet Kalsi, Jatinderpal
Gentry-Maharaj, Aleksandra
Ryan, Andy
Singh, Naveena
Burnell, Matthew
Massingham, Susan
Apostolidou, Sophia
Sharma, Aarti
Williamson, Karin
Seif, Mourad
Mould, Tim
Woolas, Robert
Dobbs, Stephen
Leeson, Simon
Fallowfield, Lesley
Skates, Steven J.
Parmar, Mahesh
Campbell, Stuart
Jacobs, Ian
McGuire, Alistair
Menon, Usha
author_sort Kalsi, Jatinderpal
collection PubMed
description SIMPLE SUMMARY: The United Kingdom Collaborative Trial of Ovarian Cancer Screening was undertaken to assess whether screening postmenopausal women from the general population might result in detection of ovarian/tubal cancers at an earlier stage and thus save lives. One of the screening strategies tested was a yearly transvaginal ultrasound scan of the ovaries (USS). Following the initial screen, 44,799 of the 50,639 women in the USS group went on to have a further 280,534 annual scans during April 2002–December 2011. Abnormalities leading to surgery were detected in 960 women of whom 113 (80 invasive epithelial) had ovarian/tubal cancer. Ovarian/tubal cancer was missed in 52 (50 invasive epithelial) women. Of the screen-detected cancers, 37.5% and missed cancers 6% were early stage(I/II). The number (detection rate 61.5%; 80/130) and advanced stage of the missed invasive cancers suggests that a yearly ultrasound scan may not be suitable for screening average risk women for ovarian cancer. ABSTRACT: Randomised controlled trials of ovarian cancer (OC) screening have not yet demonstrated an impact on disease mortality. Meanwhile, the screening data from clinical trials represents a rich resource to understand the performance of modalities used. We report here on incidence screening in the ultrasound arm of UKCTOCS. 44,799 of the 50,639 women who were randomised to annual screening with transvaginal ultrasound attended annual incidence screening between 28 April 2002 and 31 December 2011. Transvaginal ultrasound was used both as the first and the second line test. Participants were followed up through electronic health record linkage and postal questionnaires. Out of 280,534 annual incidence screens, 960 women underwent screen-positive surgery. 113 had ovarian/tubal cancer (80 invasive epithelial). Of the screen-detected invasive epithelial cancers, 37.5% (95% CI: 26.9–49.0) were Stage I/II. An additional 52 (50 invasive epithelial) were diagnosed within one year of their last screen. Of the 50 interval epithelial cancers, 6.0% (95% CI: 1.3–16.5) were Stage I/II. For detection of all ovarian/tubal cancers diagnosed within one year of screen, the sensitivity, specificity, and positive predictive values were 68.5% (95% CI: 60.8–75.5), 99.7% (95% CI: 99.7–99.7), and 11.8% (95% CI: 9.8–14) respectively. When the analysis was restricted to invasive epithelial cancers, sensitivity, specificity and positive predictive values were 61.5% (95% CI: 52.6–69.9); 99.7% (95% CI: 99.7–99.7) and 8.3% (95% CI: 6.7–10.3), with 12 surgeries per screen positive. The low sensitivity coupled with the advanced stage of interval cancers suggests that ultrasound scanning as the first line test might not be suitable for population screening for ovarian cancer. Trial registration: ISRCTN22488978. Registered on 6 April 2000.
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spelling pubmed-79228432021-03-03 Performance Characteristics of the Ultrasound Strategy during Incidence Screening in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) Kalsi, Jatinderpal Gentry-Maharaj, Aleksandra Ryan, Andy Singh, Naveena Burnell, Matthew Massingham, Susan Apostolidou, Sophia Sharma, Aarti Williamson, Karin Seif, Mourad Mould, Tim Woolas, Robert Dobbs, Stephen Leeson, Simon Fallowfield, Lesley Skates, Steven J. Parmar, Mahesh Campbell, Stuart Jacobs, Ian McGuire, Alistair Menon, Usha Cancers (Basel) Article SIMPLE SUMMARY: The United Kingdom Collaborative Trial of Ovarian Cancer Screening was undertaken to assess whether screening postmenopausal women from the general population might result in detection of ovarian/tubal cancers at an earlier stage and thus save lives. One of the screening strategies tested was a yearly transvaginal ultrasound scan of the ovaries (USS). Following the initial screen, 44,799 of the 50,639 women in the USS group went on to have a further 280,534 annual scans during April 2002–December 2011. Abnormalities leading to surgery were detected in 960 women of whom 113 (80 invasive epithelial) had ovarian/tubal cancer. Ovarian/tubal cancer was missed in 52 (50 invasive epithelial) women. Of the screen-detected cancers, 37.5% and missed cancers 6% were early stage(I/II). The number (detection rate 61.5%; 80/130) and advanced stage of the missed invasive cancers suggests that a yearly ultrasound scan may not be suitable for screening average risk women for ovarian cancer. ABSTRACT: Randomised controlled trials of ovarian cancer (OC) screening have not yet demonstrated an impact on disease mortality. Meanwhile, the screening data from clinical trials represents a rich resource to understand the performance of modalities used. We report here on incidence screening in the ultrasound arm of UKCTOCS. 44,799 of the 50,639 women who were randomised to annual screening with transvaginal ultrasound attended annual incidence screening between 28 April 2002 and 31 December 2011. Transvaginal ultrasound was used both as the first and the second line test. Participants were followed up through electronic health record linkage and postal questionnaires. Out of 280,534 annual incidence screens, 960 women underwent screen-positive surgery. 113 had ovarian/tubal cancer (80 invasive epithelial). Of the screen-detected invasive epithelial cancers, 37.5% (95% CI: 26.9–49.0) were Stage I/II. An additional 52 (50 invasive epithelial) were diagnosed within one year of their last screen. Of the 50 interval epithelial cancers, 6.0% (95% CI: 1.3–16.5) were Stage I/II. For detection of all ovarian/tubal cancers diagnosed within one year of screen, the sensitivity, specificity, and positive predictive values were 68.5% (95% CI: 60.8–75.5), 99.7% (95% CI: 99.7–99.7), and 11.8% (95% CI: 9.8–14) respectively. When the analysis was restricted to invasive epithelial cancers, sensitivity, specificity and positive predictive values were 61.5% (95% CI: 52.6–69.9); 99.7% (95% CI: 99.7–99.7) and 8.3% (95% CI: 6.7–10.3), with 12 surgeries per screen positive. The low sensitivity coupled with the advanced stage of interval cancers suggests that ultrasound scanning as the first line test might not be suitable for population screening for ovarian cancer. Trial registration: ISRCTN22488978. Registered on 6 April 2000. MDPI 2021-02-18 /pmc/articles/PMC7922843/ /pubmed/33670571 http://dx.doi.org/10.3390/cancers13040858 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalsi, Jatinderpal
Gentry-Maharaj, Aleksandra
Ryan, Andy
Singh, Naveena
Burnell, Matthew
Massingham, Susan
Apostolidou, Sophia
Sharma, Aarti
Williamson, Karin
Seif, Mourad
Mould, Tim
Woolas, Robert
Dobbs, Stephen
Leeson, Simon
Fallowfield, Lesley
Skates, Steven J.
Parmar, Mahesh
Campbell, Stuart
Jacobs, Ian
McGuire, Alistair
Menon, Usha
Performance Characteristics of the Ultrasound Strategy during Incidence Screening in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
title Performance Characteristics of the Ultrasound Strategy during Incidence Screening in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
title_full Performance Characteristics of the Ultrasound Strategy during Incidence Screening in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
title_fullStr Performance Characteristics of the Ultrasound Strategy during Incidence Screening in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
title_full_unstemmed Performance Characteristics of the Ultrasound Strategy during Incidence Screening in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
title_short Performance Characteristics of the Ultrasound Strategy during Incidence Screening in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
title_sort performance characteristics of the ultrasound strategy during incidence screening in the uk collaborative trial of ovarian cancer screening (ukctocs)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922843/
https://www.ncbi.nlm.nih.gov/pubmed/33670571
http://dx.doi.org/10.3390/cancers13040858
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