Increasing Mean Age of Head and Neck Cancer Patients at a German Tertiary Referral Center

SIMPLE SUMMARY: We detected an increase in the mean age at diagnosis among 2450 patients with head and neck carcinoma diagnosed between 2004 and 2018 in the head and neck cancer center Ulm (Germany) in comparison to the mean age in the general population of the main catchment area. Carcinoma incidences were rising too. The steepest ascent in incidence rates was found in the age group >70 years of age. These results indicate that health care providers need to prepare for an increasingly older group of cancer patients. This study is the first step to a nationwide analysis among German patients. ABSTRACT: Background: The impact of demographic change on the age at diagnosis in German head and neck cancer (HNC) patients is unclear. Here we present an evaluation of aging trends in HNC at a tertiary referral center. Methods: Retrospective cohort study on aging trends at the initial diagnosis of newly diagnosed patients with HNC between 2004 and 2018 at the head and neck cancer center Ulm in relation to demographic data of the catchment area. Results: The study population consisted of 2450 individuals diagnosed with HNC with a mean age of 62.84 (±11.67) years. We observed a significant increase in annual incidence rates and mean age over time. Mean age among HNC patients increased significantly more than among the population in the catchment area. Whereas the incidence rate of patients <50 years did not change, the incidence of HNC patients aged ≥70 years increased the most. The mean patient age in the main tumor sites increased significantly. Surprisingly, HPV-positive patients were not younger than HPV-negative patients, but showed a non-significant trend towards a higher mean age (63.0 vs. 60.7 years). Conclusions: Increasing incidence rates in older patients pose a challenge for health care systems. A nationwide study is needed to assess the dynamics and impact of aging on the incidence of HNC.