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Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis

Polydimethylsiloxane (PDMS) is a biocompatible polymer that has been applied in many fields. However, the surface hydrophobicity of PDMS can limit successful implementation, and this must be reduced by surface modification to improve biocompatibility. In this study, we modified the PDMS surface with...

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Autores principales: Joo, Haejin, Park, Jonghyun, Sutthiwanjampa, Chanutchamon, Kim, Hankoo, Bae, Taehui, Kim, Wooseob, Choi, Jinhwa, Kim, Mikyung, Kang, Shinhyuk, Park, Hansoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922955/
https://www.ncbi.nlm.nih.gov/pubmed/33671146
http://dx.doi.org/10.3390/pharmaceutics13020269
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author Joo, Haejin
Park, Jonghyun
Sutthiwanjampa, Chanutchamon
Kim, Hankoo
Bae, Taehui
Kim, Wooseob
Choi, Jinhwa
Kim, Mikyung
Kang, Shinhyuk
Park, Hansoo
author_facet Joo, Haejin
Park, Jonghyun
Sutthiwanjampa, Chanutchamon
Kim, Hankoo
Bae, Taehui
Kim, Wooseob
Choi, Jinhwa
Kim, Mikyung
Kang, Shinhyuk
Park, Hansoo
author_sort Joo, Haejin
collection PubMed
description Polydimethylsiloxane (PDMS) is a biocompatible polymer that has been applied in many fields. However, the surface hydrophobicity of PDMS can limit successful implementation, and this must be reduced by surface modification to improve biocompatibility. In this study, we modified the PDMS surface with a hydrogel and investigated the effect of this on hydrophilicity, bacterial adhesion, cell viability, immune response, and biocompatibility of PDMS. Hydrogels were created from hyaluronic acid and gelatin using a Schiff-base reaction. The PDMS surface and hydrogel were characterized using nuclear magnetic resonance, X-ray photoelectron spectroscopy, attenuated total reflection Fourier-transform infrared spectroscopy, and scanning electron microscopy. The hydrophilicity of the surface was confirmed via a decrease in the water contact angle. Bacterial anti-adhesion was demonstrated for Pseudomonas aeruginosa, Ralstonia pickettii, and Staphylococcus epidermidis, and viability and improved distribution of human-derived adipose stem cells were also confirmed. Decreased capsular tissue responses were observed in vivo with looser collagen distribution and reduced cytokine expression on the hydrogel-coated surface. Hydrogel coating on treated PDMS is a promising method to improve the surface hydrophilicity and biocompatibility for surface modification of biomedical applications.
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spelling pubmed-79229552021-03-03 Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis Joo, Haejin Park, Jonghyun Sutthiwanjampa, Chanutchamon Kim, Hankoo Bae, Taehui Kim, Wooseob Choi, Jinhwa Kim, Mikyung Kang, Shinhyuk Park, Hansoo Pharmaceutics Article Polydimethylsiloxane (PDMS) is a biocompatible polymer that has been applied in many fields. However, the surface hydrophobicity of PDMS can limit successful implementation, and this must be reduced by surface modification to improve biocompatibility. In this study, we modified the PDMS surface with a hydrogel and investigated the effect of this on hydrophilicity, bacterial adhesion, cell viability, immune response, and biocompatibility of PDMS. Hydrogels were created from hyaluronic acid and gelatin using a Schiff-base reaction. The PDMS surface and hydrogel were characterized using nuclear magnetic resonance, X-ray photoelectron spectroscopy, attenuated total reflection Fourier-transform infrared spectroscopy, and scanning electron microscopy. The hydrophilicity of the surface was confirmed via a decrease in the water contact angle. Bacterial anti-adhesion was demonstrated for Pseudomonas aeruginosa, Ralstonia pickettii, and Staphylococcus epidermidis, and viability and improved distribution of human-derived adipose stem cells were also confirmed. Decreased capsular tissue responses were observed in vivo with looser collagen distribution and reduced cytokine expression on the hydrogel-coated surface. Hydrogel coating on treated PDMS is a promising method to improve the surface hydrophilicity and biocompatibility for surface modification of biomedical applications. MDPI 2021-02-17 /pmc/articles/PMC7922955/ /pubmed/33671146 http://dx.doi.org/10.3390/pharmaceutics13020269 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Joo, Haejin
Park, Jonghyun
Sutthiwanjampa, Chanutchamon
Kim, Hankoo
Bae, Taehui
Kim, Wooseob
Choi, Jinhwa
Kim, Mikyung
Kang, Shinhyuk
Park, Hansoo
Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis
title Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis
title_full Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis
title_fullStr Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis
title_full_unstemmed Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis
title_short Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis
title_sort surface coating with hyaluronic acid-gelatin-crosslinked hydrogel on gelatin-conjugated poly(dimethylsiloxane) for implantable medical device-induced fibrosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922955/
https://www.ncbi.nlm.nih.gov/pubmed/33671146
http://dx.doi.org/10.3390/pharmaceutics13020269
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