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Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review

This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus,...

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Detalles Bibliográficos
Autores principales: Michelsen-Correa, Stephani, Martin, Clyde F., Kirk, Andrea B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922990/
https://www.ncbi.nlm.nih.gov/pubmed/33670707
http://dx.doi.org/10.3390/ijerph18041975
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author Michelsen-Correa, Stephani
Martin, Clyde F.
Kirk, Andrea B.
author_facet Michelsen-Correa, Stephani
Martin, Clyde F.
Kirk, Andrea B.
author_sort Michelsen-Correa, Stephani
collection PubMed
description This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus, lead, antimony, selenium, tin, vanadium, and zinc. Because of the lack of detail in the statistics it is not possible to do a rigorous meta-analysis. What stands out is that almost every study had subjects with seemingly large amounts of at least one of the metals. The significance of metals in meconium is not clear beyond an indication of exposure although some studies have correlated metals in meconium to a number of adverse outcomes. A number of outstanding questions have been identified that, if resolved, would greatly increase the utility of meconium analysis for assessment of long-term gestational metals exposures. Among these are questions of the developmental and long-term significance of metals detected in meconium, the kinetics and interactions among metals in maternal and fetal compartments and questions on best methods for meconium analyses.
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spelling pubmed-79229902021-03-03 Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review Michelsen-Correa, Stephani Martin, Clyde F. Kirk, Andrea B. Int J Environ Res Public Health Review This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus, lead, antimony, selenium, tin, vanadium, and zinc. Because of the lack of detail in the statistics it is not possible to do a rigorous meta-analysis. What stands out is that almost every study had subjects with seemingly large amounts of at least one of the metals. The significance of metals in meconium is not clear beyond an indication of exposure although some studies have correlated metals in meconium to a number of adverse outcomes. A number of outstanding questions have been identified that, if resolved, would greatly increase the utility of meconium analysis for assessment of long-term gestational metals exposures. Among these are questions of the developmental and long-term significance of metals detected in meconium, the kinetics and interactions among metals in maternal and fetal compartments and questions on best methods for meconium analyses. MDPI 2021-02-18 2021-02 /pmc/articles/PMC7922990/ /pubmed/33670707 http://dx.doi.org/10.3390/ijerph18041975 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Michelsen-Correa, Stephani
Martin, Clyde F.
Kirk, Andrea B.
Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review
title Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review
title_full Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review
title_fullStr Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review
title_full_unstemmed Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review
title_short Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review
title_sort evaluation of fetal exposures to metals and metalloids through meconium analyses: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922990/
https://www.ncbi.nlm.nih.gov/pubmed/33670707
http://dx.doi.org/10.3390/ijerph18041975
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