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Bio-chemo-mechanics of the thoracic aorta

The pathophysiology of thoracic aortic aneurysm and dissection is poorly understood, despite high mortality. An evidence review was conducted to examine the biomechanical, chemical and genetic factors involved in thoracic aortic pathology. The composition of connective tissue and smooth muscle cells...

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Detalles Bibliográficos
Autores principales: Iddawela, Sashini, Ravendren, Andrew, Harky, Amer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923035/
https://www.ncbi.nlm.nih.gov/pubmed/33659859
http://dx.doi.org/10.1530/VB-20-0015
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author Iddawela, Sashini
Ravendren, Andrew
Harky, Amer
author_facet Iddawela, Sashini
Ravendren, Andrew
Harky, Amer
author_sort Iddawela, Sashini
collection PubMed
description The pathophysiology of thoracic aortic aneurysm and dissection is poorly understood, despite high mortality. An evidence review was conducted to examine the biomechanical, chemical and genetic factors involved in thoracic aortic pathology. The composition of connective tissue and smooth muscle cells can mediate important mechanical properties that allow the thoracic aorta to withstand and transmit pressures. Genetic syndromes can affect connective tissue and signalling proteins that interrupt smooth muscle function, leading to tissue failure. There are complex interplaying factors that maintain thoracic aortic function in health and are disrupted in disease, signifying an area for extensive research.
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spelling pubmed-79230352021-03-02 Bio-chemo-mechanics of the thoracic aorta Iddawela, Sashini Ravendren, Andrew Harky, Amer Vasc Biol Review The pathophysiology of thoracic aortic aneurysm and dissection is poorly understood, despite high mortality. An evidence review was conducted to examine the biomechanical, chemical and genetic factors involved in thoracic aortic pathology. The composition of connective tissue and smooth muscle cells can mediate important mechanical properties that allow the thoracic aorta to withstand and transmit pressures. Genetic syndromes can affect connective tissue and signalling proteins that interrupt smooth muscle function, leading to tissue failure. There are complex interplaying factors that maintain thoracic aortic function in health and are disrupted in disease, signifying an area for extensive research. Bioscientifica Ltd 2021-01-12 /pmc/articles/PMC7923035/ /pubmed/33659859 http://dx.doi.org/10.1530/VB-20-0015 Text en © 2021 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Iddawela, Sashini
Ravendren, Andrew
Harky, Amer
Bio-chemo-mechanics of the thoracic aorta
title Bio-chemo-mechanics of the thoracic aorta
title_full Bio-chemo-mechanics of the thoracic aorta
title_fullStr Bio-chemo-mechanics of the thoracic aorta
title_full_unstemmed Bio-chemo-mechanics of the thoracic aorta
title_short Bio-chemo-mechanics of the thoracic aorta
title_sort bio-chemo-mechanics of the thoracic aorta
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923035/
https://www.ncbi.nlm.nih.gov/pubmed/33659859
http://dx.doi.org/10.1530/VB-20-0015
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